Gene Symbol | SLC17A8 |
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Entrez Gene | 246213 |
Alt Symbol | DFNA25, VGLUT3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 17 (vesicular glutamate transporter), member 8 |
Other Description | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8|solute carrier family 17 member 8|vesicular glutamate transporter 3 |
Swissprots | B7ZKV4 B3KXZ6 Q8NDX2 Q17RQ8 |
Accessions | EAW97637 Q8NDX2 AJ459241 CAD30553 AK128319 BAG54658 BC117229 AAI17230 BC143396 AAI43397 HQ258284 ADR83038 NM_001145288 NP_001138760 NM_139319 NP_647480 |
Function | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:12151341}. |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}. |
Tissue Specificity | Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus. {ECO:0000269|PubMed:12151341}. |
Top Pathways | Synaptic vesicle cycle, Glutamatergic synapse, Nicotine addiction, Retrograde endocannabinoid signaling |
VGLUT3 CRISPR/Cas9 KO Plasmid (h) - sc-410393 from Santa Cruz Biotechnology
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VGLUT3 HDR Plasmid (h) - sc-410393-HDR from Santa Cruz Biotechnology
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VGLUT3 Double Nickase Plasmid (h) - sc-410393-NIC from Santa Cruz Biotechnology
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VGLUT3 Double Nickase Plasmid (h2) - sc-410393-NIC-2 from Santa Cruz Biotechnology
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VGLUT3 CRISPR Activation Plasmid (h) - sc-410393-ACT from Santa Cruz Biotechnology
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VGLUT3 CRISPR Activation Plasmid (h2) - sc-410393-ACT-2 from Santa Cruz Biotechnology
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VGLUT3 Lentiviral Activation Particles (h) - sc-410393-LAC from Santa Cruz Biotechnology
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VGLUT3 Lentiviral Activation Particles (h2) - sc-410393-LAC-2 from Santa Cruz Biotechnology
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VGLUT3 siRNA (h) - sc-42334 from Santa Cruz Biotechnology
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VGLUT3 shRNA Plasmid (h) - sc-42334-SH from Santa Cruz Biotechnology
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VGLUT3 shRNA (h) Lentiviral Particles - sc-42334-V from Santa Cruz Biotechnology
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VGluT3 RNAi - H00246213-R01 from Novus Biologicals
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MISSION® esiRNA - EHU055791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2536 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2536 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10620 from Sigma-Aldrich
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SLC17A8 siRNA (Human) - CRJ6619 from Cohesion Biosciences
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SLC17A8 - MBS8226366 from MyBioSource
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shRNA set against Human SLC17A8 (NM_139319.2) - SHH408800 from Creative biogene
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SLC17A8 shRNA Plasmid (Human) - CHJ6619 from Cohesion Biosciences
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SLC17A8 miRNA 3'UTR clone - MiUTR4H-TG08174 from Creative biogene
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