Gene Symbol | EPX |
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Entrez Gene | 8288 |
Alt Symbol | EPO, EPP, EPX-PEN |
Species | Human |
Gene Type | protein-coding |
Description | eosinophil peroxidase |
Other Description | - |
Swissprots | Q4TVP3 P11678 |
Accessions | AAA58458 AAY43126 EAW94479 EAW94480 P11678 AJ705406 AL597635 BC111602 AAI11603 BM147889 X14346 CAA32530 NM_000502 NP_000493 |
Function | Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. {ECO:0000269|PubMed:12540536, ECO:0000269|PubMed:18694936}. |
Subcellular Location | Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. |
Top Pathways | Asthma |
EPX CRISPR/Cas9 KO Plasmid (h) - sc-402513 from Santa Cruz Biotechnology
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EPX HDR Plasmid (h) - sc-402513-HDR from Santa Cruz Biotechnology
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EPX Double Nickase Plasmid (h) - sc-402513-NIC from Santa Cruz Biotechnology
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EPX Double Nickase Plasmid (h2) - sc-402513-NIC-2 from Santa Cruz Biotechnology
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EPX CRISPR Activation Plasmid (h) - sc-402513-ACT from Santa Cruz Biotechnology
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EPX CRISPR Activation Plasmid (h2) - sc-402513-ACT-2 from Santa Cruz Biotechnology
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EPX Lentiviral Activation Particles (h) - sc-402513-LAC from Santa Cruz Biotechnology
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EPX Lentiviral Activation Particles (h2) - sc-402513-LAC-2 from Santa Cruz Biotechnology
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EPX siRNA (h) - sc-60014 from Santa Cruz Biotechnology
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EPX shRNA Plasmid (h) - sc-60014-SH from Santa Cruz Biotechnology
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EPX shRNA (h) Lentiviral Particles - sc-60014-V from Santa Cruz Biotechnology
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Erythropoietin RNAi - H00002056-R01 from Novus Biologicals
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MISSION® esiRNA - EHU033041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1726 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1726 from Sigma-Aldrich
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EPX siRNA (Human) - CRH5423 from Cohesion Biosciences
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EPX - MBS827676 from MyBioSource
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EPX CRISPR/Cas9 KO Plasmid (h2) - sc-402513-KO-2 from Santa Cruz Biotechnology
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EPX HDR Plasmid (h2) - sc-402513-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human EPX (NM_000502.4) - SHH286741 from Creative biogene
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Human EPX siRNA - orb265925 from Biorbyt
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EPX shRNA Plasmid (Human) - CHH5423 from Cohesion Biosciences
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EPX miRNA 3'UTR clone - MiUTR3H-00743 from Creative biogene
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