ABCB1

Gene Symbol ABCB1
Entrez Gene 5243
Alt Symbol ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family B (MDR/TAP), member 1
Other Description P-glycoprotein 1|colchicin sensitivity|doxorubicin resistance|multidrug resistance protein 1
Swissprots A8K294 P08183 Q12755 Q14812 B5AK60
Accessions AAA59576 AAA88047 AAA88048 AAB70218 AAM49149 AAR99172 AAW82430 ACH96452 AEC13104 AEC13105 AEC13106 AEC13107 AEC13108 AEC13109 AEC13110 AEC13111 AEC13112 AEC13113 AEC13114 AEC13115 AEC13116 AEC13117 AEC13118 AEC13119 AEC13120 AEC13121 AEC13122 AEC13123 AEC13124 AEC13125 AEC13126 AEC13127 AEC13128 AEC13129 AEC13130 AEC13131 AEC13132 AEC13133 AEC13134 AEC13135 AEC13136 AEC13137 AEC13138 AEC13139 AEC13140 AEC13141 AEC13142 AEC13143 AEC13144 AEC13145 AEC13146 AEC13147 AEC13148 AEC13149 AEC13150 AEC13151 AEC13152 AEC13153 AEC13154 AEC13155 AEC13156 AEC13157 AEC13158 AEC13159 AEC13160 AEC13161 AEC13162 AEC13163 AEC13164 AEC13165 AEC13166 AEC13167 AEC13168 AEC13169 AEC13170 AEC13171 AEC13172 AEC13173 AEC13174 AEC13175 AEC13176 AEC13177 AEC13178 AEC13179 AEC13180 AEC13181 AEC13182 AEC13183 AEC13184 AEC13185 AEC13186 AEC13187 AEC13188 AEC13189 AEC13190 AEC13191 AEC13192 AEC13193 AEC13194 AEC13195 AEC13196 AEC13197 AEC13198 AEC13199 AEC13200 AEC13201 AEC13202 AEC13203 AEC13204 AEC13205 AEC13206 AEC13207 AEC13208 AEC13209 AEC13210 AEC13211 AEC13212 AEC13213 AEC13214 AEC13215 AEC13216 AEC13217 AEC13218 AEC13219 AEC13220 AEC13221 AEC13222 AEC13223 AEC13224 AEC13225 AEC13226 AEC13227 AEC13228 AEC13229 AEC13230 AEC13231 AEC13232 AEC13233 AEC13234 AEC13235 AEC13236 AEC13237 AEC13238 AEC13239 AEC13240 AEC13241 AEC13242 AEC13243 AEC13244 AEC13245 AEC13246 AEC13247 AEC13248 AEC13249 AEC13250 AEC13251 AEC13252 AEC13253 AEC13254 AEC13255 AEC13256 AEC13257 AEC13258 AEC13259 AEC13260 AEC13261 AEC13262 AEC13263 AEC13264 AEC13265 AEC13266 AEC13267 AEC13268 AEC13269 AEC13270 AEC13271 AEC13272 AEC13273 AEC13274 AEC13275 AEC13276 AEC13277 AEC13278 AEC13279 AEC13280 AEC13281 AEC13282 AEC13283 AEC13284 AEC13285 AEC13286 AEC13287 AEC13288 AEC13289 AEC13290 AEC13291 AEC13292 AEC13293 AEC13295 AEC13296 AEC13297 AEC13298 AEC13299 AEC13300 CAA41558 EAL24173 EAW76940 EAW76941 EAW76942 EAW76943 P08183 AA776371 AB208970 BAD92207 AF016535 AAB69423 AF345623 AF345624 AF345625 AF345626 AK290159 BAF82848 AK308467 AM393352 CAL38230 AY425005 AAR91621 AY425006 AAR91622 AY425007 AAR83914 AY452673 BC130424 AAI30425 BQ720763 BQ882401 BX509020 CB164676 EU852583 ACF94687 EU854148 ACF94688 M14758 AAA59575 NM_000927 NP_000918
Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Tissue Specificity Expressed in liver, kidney, small intestine and brain.
Top Pathways ABC transporters, Bile secretion, MicroRNAs in cancer

MDR1/ABCB1 (E1Y7S) Rabbit mAb - 13978 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1Y7S
Western blot analysis of extracts from Hep G2, MCF7 and mIMCD-3 cells using MDR1/ABCB1 (E1Y7S) Rabbit mAb (upper) and β-Actin (13E5) Rabbit mAb #4970 (lower).

MDR1/ABCB1 (E1Y7B) Rabbit mAb - 13342 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1Y7B
Western blot analysis of extracts from various cell lines using MDR1/ABCB1 (E1Y7B) Rabbit mAb and β-Actin (13E5) Rabbit mAb #4970

MDR1/ABCB1 (D3H1Q) Rabbit mAb - 12683 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3H1Q
Western blot analysis of extracts from Hep G2 and DLD-1 cells using MDR1/ABCB1 (D3H1Q) Rabbit mAb.

MDR1/ABCB1 Antibody - 12273 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Mdr (C-19) - sc-1517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mdr (C-19): sc-1517. Western blot analysis of Mdr (P-glycoprotein) expression in MES-SA/Dx5 whole cell lysate.

Mdr (H-241) - sc-8313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mdr (H-241): sc-8313. Immunofluorescence staining of methanol-fixed MES-SA/Dx5 cells showing membrane localization.

Mdr-1 (D-11) - sc-55510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mdr-1 (D-11): sc-55510. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

Mdr-1 (G-1) - sc-13131 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mdr-1 (G-1): sc-13131. Western blot analysis of Mdr-1 expression in MES-SA/Dx5 whole cell lysate.

Mdr-1 (UIC2) - sc-73354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Mdr-1 (3H2833) - sc-71557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal

Anti-P Glycoprotein antibody - ab129450 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P Glycoprotein antibody (ab129450) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-P Glycoprotein antibody - ab98322 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-P Glycoprotein antibody (ab98322) at 1 µg/ml (in 5% skim milk / PBS buffer) + NCI-H226 cell lysate at 10 µg

Anti-P Glycoprotein antibody - ab135867 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labelling P Glycoprotein with ab135867 at 1/50 dilution.

Anti-P Glycoprotein antibody - ab189780 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P Glycoprotein antibody (ab189780) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-P Glycoprotein antibody [4E3] - ab10333 from Abcam

Prices $376.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 4E3

Anti-P Glycoprotein antibody [EPR10363] - ab170903 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10363
Flow cytometry analysis of permeabilized 293T cells labeling P Glycoprotein (red), using ab170903 at a 1/100 dilution, and negative control cells probed with a rabbit IgG (green)

Anti-P Glycoprotein antibody [EPR10364] - ab168337 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10364
All lanes : Anti-P Glycoprotein antibody [EPR10364] (ab168337) at 1/1000 dilutionLane 1 : HeLa cell lysatesLane 2 : 293T cell lysatesLane 3 : Human fetal brain lysatesLysates/proteins at 10 µg per lane.

Anti-P Glycoprotein antibody [EPR10364-57] - ab170904 from Abcam

Prices $398.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10364-57
All lanes : Anti-P Glycoprotein antibody [EPR10364-57] (ab170904) at 1/200 dilution (unpurified)Lane 1 : HepG2 cell lysateLane 2 : Mouse brain tissue lysateLane 3 : Rat brain tissue lysateLysates/proteins at 20 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-P Glycoprotein antibody [F4] - ab80594 from Abcam

Prices $373.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone F4

Anti-P Glycoprotein antibody [JSB-1] - ab3366 from Abcam

Prices $385.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone JSB-1
ab3366 (4µg/ml) staining p Glycoprotein in human liver, using an automated system (DAKO Autostainer Plus). Using this protocol there is a cell membrane staining of a subpopulation of hepatocytes.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer EDTA pH 9.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-P Glycoprotein antibody [JSB-1], prediluted - ab51893 from Abcam

Prices $370.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal
Clone JSB-1

Anti-P Glycoprotein antibody [UIC2] - ab166957 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone UIC2

Anti-P Glycoprotein antibody [UIC2] (FITC) - ab66250 from Abcam

Prices $188.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone UIC2

Anti-P Glycoprotein antibody [UIC2] (Phycoerythrin) - ab93590 from Abcam

Prices $191.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone UIC2
Staining of the 8226/S (blue histogram) and 8226 DOX40 (purple histogram) cell lines with PE Mouse IgG2a, K Isotype Control (left) or ab93590 (right). Total viable cells were used for analysis.

Anti-P Glycoprotein antibody - Cytoplasmic domain - ab140699 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue (proximal convoluted tubules) labelling P Glycoprotein with ab140699 at 2.5 µg/ml.
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