| Gene Symbol |
YAP1
|
| Entrez Gene |
10413
|
| Alt Symbol |
COB1, YAP, YAP2, YAP65, YKI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Yes-associated protein 1
|
| Other Description |
65 kDa Yes-associated protein|protein yorkie homolog|transcriptional coactivator YAP1|yes-associated protein 2|yes-associated protein YAP65 homolog|yorkie homolog
|
| Swissprots |
Q7Z574 E3WEB6 E3WEB5 K0L1G3 K0KQ18 Q8IUY9 K0L195 B7ZA01 P46937 E9PRV2 K0KYZ8 F5H202 B4DTY1
|
| Accessions |
CAA56672 CCH22597 CCH22598 EAW67011 EAW67012 EAW67013 EAW67014 EAW67015 P46937 AA854862 AB567720 BAJ41471 AB567721 BAJ41472 AI128142 AK300414 BAG62143 AK304485 BAG65295 AK310620 AK316116 BAH14487 AL832620 CAD89963 AY316529 AAP92710 BC026212 BC038235 AAH38235 BU073244 CX780993 DC419625 HE864159 CCI79618 HE864160 CCI79619 HE864161 CCI79620 HE864162 CCI79621 HE864163 CCI79622 XM_005271378 XP_005271435 XM_005271380 XP_005271437 XM_005271381 XP_005271438 XM_005271383 XP_005271440 XM_011542555 XP_011540857 XM_011542556 XP_011540858 NM_001130145 NP_001123617 NM_001195044 NP_001181973 NM_001195045 NP_001181974 NM_001282097 NP_001269026 NM_001282098 NP_001269027 NM_001282099 NP_001269028 NM_001282100 NP_001269029 NM_001282101 NP_001269030 NM_006106 NP_006097
|
| Function |
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces translocation from the nucleus to the cytoplasm.
|
| Tissue Specificity |
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level). {ECO:0000269|PubMed:16461361, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:7782338}.
|
| Top Pathways |
Hippo signaling pathway
|