Gene Symbol | ST3GAL5 |
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Entrez Gene | 8869 |
Alt Symbol | SATI, SIAT9, SIATGM3S, ST3GalV |
Species | Human |
Gene Type | protein-coding |
Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
Other Description | CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase|GM3 synthase|ST3Gal V|alpha 2,3-sialyltransferase V|ganglioside GM3 synthase|lactosylceramide alpha-2,3-sialyltransferase|sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) |
Swissprots | Q6YFL1 Q6NZX4 O94902 D6W5L9 Q9UNP4 Q53QU1 B3KM82 |
Accessions | AAY24147 EAW99474 EAW99475 EAW99476 EAW99477 EAW99478 EAW99479 EAW99480 Q9UNP4 AB018356 BAA33950 AF105026 AAD14634 AF119415 AAF66146 AF119417 AF119418 AF161396 AAF28956 AF344831 AK001340 BAG50894 AK124862 BAC85970 AK127346 AK295252 BAH12019 AK315955 BAH14326 AY152815 AAO16866 AY359105 AAQ89463 BC009887 BC065936 AAH65936 BI820835 CA503200 XM_005264630 XP_005264687 XM_011533143 XP_011531445 XR_939734 XR_939735 XR_939736 NM_001042437 NP_001035902 NM_003896 NP_003887 |
Function | Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). {ECO:0000269|PubMed:16934889}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis. |
Top Pathways | Glycosphingolipid biosynthesis - ganglio series |
GM3 Synthase CRISPR/Cas9 KO Plasmid (h) - sc-403919 from Santa Cruz Biotechnology
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GM3 Synthase HDR Plasmid (h) - sc-403919-HDR from Santa Cruz Biotechnology
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GM3 Synthase Double Nickase Plasmid (h) - sc-403919-NIC from Santa Cruz Biotechnology
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GM3 Synthase Double Nickase Plasmid (h2) - sc-403919-NIC-2 from Santa Cruz Biotechnology
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GM3 Synthase CRISPR Activation Plasmid (h) - sc-403919-ACT from Santa Cruz Biotechnology
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GM3 Synthase CRISPR Activation Plasmid (h2) - sc-403919-ACT-2 from Santa Cruz Biotechnology
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GM3 Synthase Lentiviral Activation Particles (h) - sc-403919-LAC from Santa Cruz Biotechnology
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GM3 Synthase Lentiviral Activation Particles (h2) - sc-403919-LAC-2 from Santa Cruz Biotechnology
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GM3 Synthase siRNA (h) - sc-72297 from Santa Cruz Biotechnology
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GM3 Synthase shRNA Plasmid (h) - sc-72297-SH from Santa Cruz Biotechnology
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GM3 Synthase shRNA (h) Lentiviral Particles - sc-72297-V from Santa Cruz Biotechnology
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ST3GAL5 RNAi - H00008869-R02 from Novus Biologicals
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ST3GAL5 RNAi - H00008869-R01 from Novus Biologicals
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MISSION® esiRNA - EHU053561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20657 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20657 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12415 from Sigma-Aldrich
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ST3GAL5 siRNA (Human) - CRH5857 from Cohesion Biosciences
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ST3GAL5 - MBS828319 from MyBioSource
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shRNA set against Human ST3GAL5 (NM_003896.3) - SHH418848 from Creative biogene
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shRNA set against Human ST3GAL5(NM_003896.3) - SHL038160 from Creative biogene
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shRNA set against Human ST3GAL5(NM_001042437.1) - SHL038214 from Creative biogene
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ST3GAL5 shRNA Plasmid (Human) - CHH5857 from Cohesion Biosciences
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ST3GAL5 miRNA 3'UTR clone - MiUTR1H-09946 from Creative biogene
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ST3GAL5 miRNA 3'UTR clone - MiUTR1H-09947 from Creative biogene
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