| Gene Symbol | Prdx1 |
|---|---|
| Entrez Gene | 18477 |
| Alt Symbol | MSP23, NkefA, OSF-3, OSF3, PAG, Paga, PrdxI, PrxI, TDX2, TPxA, Tdpx2, prx1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | peroxiredoxin 1 |
| Other Description | Trx dependent peroxide reductase 2|macrophage 23 Kd stress protein|macrophage 23 kDa stress protein|macrophage 23kDa stress protein|macrophase stress protein 22kDa|macrophase stress protein 23 kd|osteoblast specific factor 3|osteoblast-specific factor 3|peroxiredoxin-1|proliferation-associated gene A|thioredoxin dependent peroxide reductase 2|thioredoxin peroxidase 2|thioredoxin-dependent peroxide reductase 2 |
| Swissprots | Q9CWI2 Q3UBV4 P35700 |
| Accessions | AAD45323 BAA86992 EDL30594 P35700 AK002287 BAB21990 AK008711 BAB25847 AK010688 BAB27120 AK083243 BAC38827 AK145138 BAE26255 AK150797 BAE29860 AK151459 BAE30417 AK151760 BAE30667 AK163984 AK167624 BAE39676 AK169154 BAE40933 AK169992 AK184215 AK184318 BC083348 AAH83348 BC086648 AAH86648 D16142 BAA03713 D21252 BAA04796 NM_011034 NP_035164 |
| Function | Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Regulates GDPD5 function by reducing an intramolecular disulfide bond (By similarity). Cooperates with GDPD5 to drive postmitotic motor neuron differentiation. {ECO:0000250, ECO:0000269|PubMed:19766572}. |
| Subcellular Location | Cytoplasm. Melanosome {ECO:0000250}. |
| Tissue Specificity | Found in various tissues; high concentration in liver. |
| Top Pathways | Peroxisome |