| Gene Symbol |
MALSU1
|
| Entrez Gene |
115416
|
| Alt Symbol |
C7orf30, mtRsfA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial assembly of ribosomal large subunit 1
|
| Other Description |
mitochondrial assembly of ribosomal large subunit protein 1
|
| Swissprots |
A4D154 Q96EH3
|
| Accessions |
EAL24258 EAW93785 Q96EH3 AK127742 BAG54562 AK316559 BAG38148 AL832885 BC012331 AAH12331 BC065766 NM_138446 NP_612455
|
| Function |
May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. {ECO:0000269|PubMed:22238376}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:16548050, ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22238376, ECO:0000269|PubMed:22829778}. Note=Colocalizes with MRPL12 (PubMed:22238375) and/or MRPL14 (PubMed:22829778). {ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22829778}.
|