Gene Symbol | MALSU1 |
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Entrez Gene | 115416 |
Alt Symbol | C7orf30, mtRsfA |
Species | Human |
Gene Type | protein-coding |
Description | mitochondrial assembly of ribosomal large subunit 1 |
Other Description | mitochondrial assembly of ribosomal large subunit protein 1 |
Swissprots | A4D154 Q96EH3 |
Accessions | EAL24258 EAW93785 Q96EH3 AK127742 BAG54562 AK316559 BAG38148 AL832885 BC012331 AAH12331 BC065766 NM_138446 NP_612455 |
Function | May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. {ECO:0000269|PubMed:22238376}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:16548050, ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22238376, ECO:0000269|PubMed:22829778}. Note=Colocalizes with MRPL12 (PubMed:22238375) and/or MRPL14 (PubMed:22829778). {ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22829778}. |
C7orf30 CRISPR/Cas9 KO Plasmid (h) - sc-414069 from Santa Cruz Biotechnology
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C7orf30 HDR Plasmid (h) - sc-414069-HDR from Santa Cruz Biotechnology
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C7orf30 Double Nickase Plasmid (h) - sc-414069-NIC from Santa Cruz Biotechnology
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C7orf30 Double Nickase Plasmid (h2) - sc-414069-NIC-2 from Santa Cruz Biotechnology
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C7orf30 CRISPR Activation Plasmid (h) - sc-414069-ACT from Santa Cruz Biotechnology
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C7orf30 CRISPR Activation Plasmid (h2) - sc-414069-ACT-2 from Santa Cruz Biotechnology
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C7orf30 Lentiviral Activation Particles (h) - sc-414069-LAC from Santa Cruz Biotechnology
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C7orf30 Lentiviral Activation Particles (h2) - sc-414069-LAC-2 from Santa Cruz Biotechnology
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C7orf30 siRNA (h) - sc-89893 from Santa Cruz Biotechnology
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C7orf30 shRNA Plasmid (h) - sc-89893-SH from Santa Cruz Biotechnology
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C7orf30 shRNA (h) Lentiviral Particles - sc-89893-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5088 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5088 from Sigma-Aldrich
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MALSU1 siRNA (Human) - CRJ4448 from Cohesion Biosciences
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shRNA set against Human C7orf30 (NM_138446.1) - SHH252425 from Creative biogene
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Human MALSU1 siRNA - orb274949 from Biorbyt
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MALSU1 shRNA Plasmid (Human) - CHJ4448 from Cohesion Biosciences
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MALSU1 miRNA 3'UTR clone - MiUTR1H-01487 from Creative biogene
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