CRHR2

Gene Symbol CRHR2
Entrez Gene 1395
Alt Symbol CRF-RB, CRF2, CRFR2, HM-CRF
Species Human
Gene Type protein-coding
Description corticotropin releasing hormone receptor 2
Other Description CRF2 receptor, beta isoform|CRH receptor 2 variant B|CRH-R2|corticotropin-releasing factor receptor 2
Swissprots Q4QRJ4 Q13324 B3SXS6 O43461 F8WA81 B3SXS8 Q99431 B3SXT0 B2R967 B3SXS7
Accessions AAC71653 AAC71654 BAC05922 CAD69350 CAP40149 CAP40151 EAL24448 EAW93962 EAW93963 EAW93964 EAW93965 Q13324 AF011406 AAB94503 AF019381 AAB94562 AF361106 AF361107 AF361108 AK313661 BAG36414 AY449734 AAR18078 BC096830 AAH96830 CN367943 CN367944 DA808296 DB308619 EU012439 ABV59313 EU012440 ABV59314 EU012441 ABV59315 EU012442 ABV59316 EU012443 ABV59317 FJ200484 ACO54881 U34587 AAA91320 Y10151 CAA71235 Y10152 CAA71236 Y10153 XM_011515127 XP_011513429 XM_011515128 XP_011513430 XM_011515129 XP_011513431 NM_001202475 NP_001189404 NM_001202481 NP_001189410 NM_001202482 NP_001189411 NM_001202483 NP_001189412 NM_001883 NP_001874
Function G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22689579}; Multi-pass membrane protein {ECO:0000269|PubMed:22689579}.
Top Pathways Neuroactive ligand-receptor interaction

CRF-RII (C-15) - sc-20550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CRF-RII (C-15): sc-20550. Western blot analysis of CRF-RII expression in BC<sub>3</sub>H1 (A) and U-87 MG (B) whole cell lysates.

CRF-RII (N-20) - sc-1826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CRF-RII (W-17) - sc-20549 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Corticotropin Releasing Factor Receptor 2 antibody - ab203585 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin embedded mouse kidney tissue labeling Corticotropin Releasing Factor Receptor 2 with ab203585 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-Corticotropin Releasing Factor Receptor 2 antibody - ab136006 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Corticotropin Releasing Factor Receptor 2 antibody (ab136006) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-Corticotropin Releasing Factor Receptor 2 antibody - ab167379 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Corticotropin Releasing Factor Receptor 2 antibody (ab167379) at 1 µg/mlLane 1 : Corticotropin Releasing Factor Receptor 2 transfected 293T cell lysateLane 2 : Non transfected lysateLysates/proteins at 50 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-Corticotropin Releasing Factor Receptor 2 antibody - N-terminal - ab175568 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Formalin-fixed, Paraffin-embedded Mouse brain tissue labeling Corticotropin Releasing Factor Receptor 2 with ab175568 at 1/10 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CRHR2 / CRF2 Receptor Antibody (N-Terminus) - LS-C140644 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (Extracellular Domain) IHC-plus™ - LS-A3573 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRHR2 antibody LS-A3573 IHC of human brain, choroid plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CRHR2 / CRF2 Receptor Antibody (aa68-117) - LS-C151620 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRHR2 / CRF2 antibody Western Blot of Fetal Brain.

Anti-CRHR2 / CRF2 Receptor Antibody (aa75-125) - LS-C148318 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CRHR2 in human brain lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148318 at 1 ug/ml. Both of the isoforms detected by LS-C148318 are blocked by the immunizing peptide.

Anti-CRHR2 / CRF2 Receptor Antibody (aa385-411, Biotin) - LS-C183805 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (N-Terminus) IHC-plus™ - LS-A3570 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRHR2 antibody LS-A3570 IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CRHR2 / CRF2 Receptor Antibody (Tyr113) - LS-C177082 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CRF-RII (Y113) pAb in extracts from COLO205 cells.

Anti-CRHR2 / CRF2 Receptor Antibody (aa385-411, CF) - LS-C183806 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (aa385-411, FITC) - LS-C183807 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (aa385-411, Rhodamine) - LS-C183808 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody - LS-C167036 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRFR2D Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CRHR2 / CRF2 Receptor Antibody (His112) - LS-C177099 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CRF-RII (H112) pAb in extracts from K562 cells.

Anti-CRHR2 / CRF2 Receptor Antibody (aa385-411) - LS-C190692 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (N-Terminus, APC) - LS-C206481 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (N-Terminus, AP) - LS-C206482 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (N-Terminus, PE) - LS-C206483 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (Internal, AP) - LS-C206484 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CRHR2 / CRF2 Receptor Antibody (Internal, APC) - LS-C206485 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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