| Gene Symbol |
CRHR2
|
| Entrez Gene |
1395
|
| Alt Symbol |
CRF-RB, CRF2, CRFR2, HM-CRF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
corticotropin releasing hormone receptor 2
|
| Other Description |
CRF2 receptor, beta isoform|CRH receptor 2 variant B|CRH-R2|corticotropin-releasing factor receptor 2
|
| Swissprots |
Q4QRJ4 Q13324 B3SXS6 O43461 F8WA81 B3SXS8 Q99431 B3SXT0 B2R967 B3SXS7
|
| Accessions |
AAC71653 AAC71654 BAC05922 CAD69350 CAP40149 CAP40151 EAL24448 EAW93962 EAW93963 EAW93964 EAW93965 Q13324 AF011406 AAB94503 AF019381 AAB94562 AF361106 AF361107 AF361108 AK313661 BAG36414 AY449734 AAR18078 BC096830 AAH96830 CN367943 CN367944 DA808296 DB308619 EU012439 ABV59313 EU012440 ABV59314 EU012441 ABV59315 EU012442 ABV59316 EU012443 ABV59317 FJ200484 ACO54881 U34587 AAA91320 Y10151 CAA71235 Y10152 CAA71236 Y10153 XM_011515127 XP_011513429 XM_011515128 XP_011513430 XM_011515129 XP_011513431 NM_001202475 NP_001189404 NM_001202481 NP_001189410 NM_001202482 NP_001189411 NM_001202483 NP_001189412 NM_001883 NP_001874
|
| Function |
G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22689579}; Multi-pass membrane protein {ECO:0000269|PubMed:22689579}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|