ATXN7L3
| Gene Symbol | ATXN7L3 |
|---|---|
| Entrez Gene | 56970 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | ataxin 7-like 3 |
| Other Description | ataxin-7-like protein 3 |
| Swissprots | Q96N40 Q8IY68 Q14CW9 Q9NPU5 |
| Accessions | CCQ43629 EAW51622 Q14CW9 AK056002 BAB71070 AK074344 AK126117 AK296689 BAG59283 AL390158 CAB99093 BC024695 BC037418 AAH37418 BC064932 BC100295 BC113595 AAI13596 BC126113 AAI26114 DQ588490 HQ258188 ADR82942 XM_011525036 XP_011523338 XM_011525037 XP_011523339 XM_011525038 XP_011523340 XM_011525039 XP_011523341 XM_011525040 XP_011523342 XM_011525041 XP_011523343 XM_011525042 XP_011523344 XM_011525043 XP_011523345 XM_011525044 XP_011523346 XM_011525045 XP_011523347 XM_011525046 XP_011523348 XM_011525047 XP_011523349 NM_001098833 NP_001092303 NM_020218 NP_064603 |
| Function | Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. {ECO:0000255|HAMAP- Rule:MF_03047, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879}. |
| Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03047}. |
ATXN7L3-Over-expression-Lysate - LY16576a from Abgent, a WuXi AppTec company
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ATXN7L3 overexpression lysate - LY412582 from Acris Antibodies
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Panoply™ Human ATXN7L3 Knockdown Stable Cell Line - CSC-DC001226 from Creative biogene
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