Gene Symbol | CLCNKB |
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Entrez Gene | 1188 |
Alt Symbol | CLCKB, ClC-K2, ClC-Kb |
Species | Human |
Gene Type | protein-coding |
Description | chloride channel, voltage-sensitive Kb |
Other Description | chloride channel protein ClC-Kb|chloride channel, kidney, B |
Swissprots | Q5T5Q8 B3KUY3 P51801 Q5T5Q7 |
Accessions | AAB65149 EAW51764 EAW51765 EAW51766 P51801 AK098217 BAG53595 AK292335 BAF85024 BC020873 AAH20873 BC033806 BC109243 DA369686 DA424588 DA623867 DA624942 DA627682 DA628551 DA633177 S80315 AAB35898 Z30644 CAA83121 XM_011540619 XP_011538921 XM_011540620 XP_011538922 XM_011540621 XP_011538923 NM_000085 NP_000076 NM_001165945 NP_001159417 |
Function | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. {ECO:0000269|PubMed:11734858}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed predominantly in the kidney. {ECO:0000269|PubMed:11734858}. |
Top Pathways | Collecting duct acid secretion |
CLC-KB CRISPR/Cas9 KO Plasmid (h) - sc-406201 from Santa Cruz Biotechnology
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CLC-KB HDR Plasmid (h) - sc-406201-HDR from Santa Cruz Biotechnology
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CLC-KB Double Nickase Plasmid (h) - sc-406201-NIC from Santa Cruz Biotechnology
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CLC-KB Double Nickase Plasmid (h2) - sc-406201-NIC-2 from Santa Cruz Biotechnology
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CLC-KB CRISPR Activation Plasmid (h) - sc-406201-ACT from Santa Cruz Biotechnology
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CLC-KB CRISPR Activation Plasmid (h2) - sc-406201-ACT-2 from Santa Cruz Biotechnology
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CLC-KB Lentiviral Activation Particles (h) - sc-406201-LAC from Santa Cruz Biotechnology
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CLC-KB Lentiviral Activation Particles (h2) - sc-406201-LAC-2 from Santa Cruz Biotechnology
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CLC-KB siRNA (h) - sc-105210 from Santa Cruz Biotechnology
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CLC-KB shRNA Plasmid (h) - sc-105210-SH from Santa Cruz Biotechnology
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CLC-KB shRNA (h) Lentiviral Particles - sc-105210-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN1622 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1622 from Sigma-Aldrich
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CLCNKB siRNA (Human) - CRH0850 from Cohesion Biosciences
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CLCNKB RNAi - H00001188-R01 from Novus Biologicals
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CLCNKB - MBS8227322 from MyBioSource
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shRNA set against Human CLCNKB (NM_000085.4) - SHH264613 from Creative biogene
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Human CLCNKB siRNA - orb261352 from Biorbyt
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CLCNKB shRNA Plasmid (Human) - CHH0850 from Cohesion Biosciences
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CLCNKB miRNA 3'UTR clone - MiUTR3H-04604 from Creative biogene
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CLCNKB miRNA 3'UTR clone - MiUTR3H-04605 from Creative biogene
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