| Gene Symbol |
HILPDA
|
| Entrez Gene |
29923
|
| Alt Symbol |
C7orf68, HIG-2, HIG2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hypoxia inducible lipid droplet-associated
|
| Other Description |
hypoxia inducible gene 2|hypoxia-inducible gene 2 protein|hypoxia-inducible lipid droplet-associated protein|hypoxia-inducible protein 2
|
| Swissprots |
Q9Y5L2 Q53HJ7 Q52LY5 A4D0Z5
|
| Accessions |
CAI70370 CCD35269 CCQ77689 CCQ77698 CCQ77707 CCQ77716 CDH48195 CDH61617 CDH61671 CDH61690 CDH88988 CDH92526 CDH92540 CDH92551 CDH92798 CDH92895 CDI44670 CDI44679 EAL24309 EAW83654 EAW83655 EAW83656 Q9Y5L2 AF144755 AAD37585 AK024729 AK222583 BAD96303 AL691669 BC001863 AAH01863 BC008573 BC093742 AAH93742 BC112183 AAI12184 CD686848 CX784347 NM_001098786 NP_001092256 NM_013332 NP_037464
|
| Function |
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. {ECO:0000269|PubMed:15930302, ECO:0000269|PubMed:20624928}.
|
| Subcellular Location |
Lipid droplet. Secreted. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level). {ECO:0000269|PubMed:15930302, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:21614900}.
|