ATRX

Gene Symbol ATRX
Entrez Gene 546
Alt Symbol ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX
Species Human
Gene Type protein-coding
Description alpha thalassemia/mental retardation syndrome X-linked
Other Description ATP-dependent helicase ATRX|DNA dependent ATPase and helicase|X-linked helicase II|X-linked nuclear protein|Zinc finger helicase|alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)|helicase 2, X-linked|transcriptional regulator ATRX
Swissprots Q5H9A2 D3DTE2 Q59H31 Q9NTS3 P46100 Q59FB5 Q15886 Q7Z2J1 P51068 Q5JWI4 Q9H0Z1
Accessions AAA20872 AAB40698 AAB40699 AAB40700 AAC51655 AAC51657 ABO43036 AGL61631 AIA09018 AIA09019 AIA09020 BAC80270 BAC80271 BAC80272 BAC80273 BAC80274 BAC80275 BAC80276 BAC80277 BAC80278 BAC80279 BAC80280 BAC80281 BAC80282 BAC80283 BAC80284 BAC80285 BAC80286 BAC80287 BAC80288 BAC80289 CAA58711 CAB90351 CAI40710 CAI42674 CAI42675 CAI42677 CAI43115 CAI43116 CAI43117 CCQ42985 CCQ42986 EAW98611 EAW98612 EAW98613 EAW98614 EAW98615 P46100 AA484729 AA732359 AB102641 BAC81110 AB208928 BAD92165 AB209545 BAD92782 AI733378 AK293241 BAH11474 AK295107 BAG58140 AK296959 BAG59503 AK297183 BAG59673 AK307791 AK308419 BC002521 AAH02521 BC156296 AAI56297 BE927791 BM714186 BQ189245 BT007188 AAP35852 BX647222 CB114986 DA759777 DA791316 DR422800 L33812 U09820 AAC50069 U72936 AAB49969 U72937 AAB49970 U72938 AAB49971 XM_005262153 XP_005262210 XM_005262154 XP_005262211 XM_005262155 XP_005262212 XM_005262156 XP_005262213 XM_005262157 XP_005262214 XM_006724666 XP_006724729 XM_006724667 XP_006724730 XM_006724668 XP_006724731 XR_938400 NM_000489 NP_000480 NM_138270 NP_612114 NM_138271
Function Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3- containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S- phase and telomeres, and the in vitro remodeling of H3.3- containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in em
Subcellular Location Nucleus. Chromosome, telomere. Nucleus, PML body. Note=Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML- nuclear bodies. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous.

ATRX (D1N2E) Rabbit mAb - 14820 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1N2E
Western blot analysis of extracts from various cell lines using ATRX (D1N2E) Rabbit mAb (upper) and Nucleolin (D4C7O) Rabbit mAb #14574. As expected, the signal for ATRX is not present in the negative cell line U2OS.

ATRX (D-5) - sc-55584 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ATRX (D-5): sc-55584. Western blot analysis of ATRX expression in HeLa (A) and NIH/3T3 (B) nuclear extracts and Nocodazole treated HeLa (C) and 3T3-L1 (D) whole cell lysates.

ATRX (D-19) - sc-10078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATRX (D-19): sc-10078. Western blot analysis of ATRX expression in HeLa nuclear extract.

ATRX (C-16) - sc-10080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATRX (C-16): sc-10080. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing nuclear and cytoplasmic staining of respiratory epithelial cells.

ATRX (H-300) - sc-15408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ATRX (H-300): sc-15408. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

Anti-ATRX antibody - ab97508 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ATRX antibody (ab97508) at 1/500 dilutionLane 1 : 293T whole cell lysateLane 2 : HepG2 whole cell lysateLane 3 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-ATRX antibody - ab72124 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling ATRX with ab72124 at 1/1000 (1µg/ml). Detection: DAB.

Anti-ATRX antibody - ab84462 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84462, at 1/250 dilution, staining ATRX in formalin-fixed, paraffin-embedded human breast carcinoma by Immunohistochemistry, using DAB detectioN.

Anti-ATRX antibody - ab21830 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-ATRX antibody (ab21830) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ugLane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ugSecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-ATRX antibody - ab54794 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54794 ATRX antibody at 1ug/ml.

Anti-ATRX antibody [38.4] - ab21088 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 38.4

Anti-ATRX antibody [CL0537] - ab188027 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone CL0537
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cerebellum tissue, labeling ATRX with ab188027 at 1/200 dilution.

Anti-ATRX antibody [GT4212] - C-terminal - ab184228 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT4212
Immunofluorescent analysis of HeLa cells (fixed in 4% paraformaldehyde at RT for 15 min) labeling ATRX with ab184228 at 1/500 dilution (Green). Hoechst 33342 staining (Blue).

Anti-RAD54L Antibody (C-Terminus, clone 60.1) IHC-plus™ - LS-B1687 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 60.1
Anti-ATRX antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1687 concentration 5 ug/ml.

Anti-ATRX Antibody (aa2161-2443) - LS-C185396 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded A549 xenograft using ATRX antibody at 1:100 dilution.

Anti-ATRX Antibody - LS-C26432 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ATRX Antibody (clone 4E3/1) - LS-C49110 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E3/1

Anti-ATRX Antibody (clone Rad544E3/1) - LS-C63157 from LifeSpan Bioscience

Prices $245.00, $345.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone Rad544E3/1

Anti-ATRX Antibody (Internal) - LS-C305834 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ATRX Antibody (aa111-160) - LS-C118900 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using ATRX Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ATRX Antibody (C-Terminus) - LS-C287876 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:1000 (1 ug/ml).

Anti-ATRX Antibody (aa904-953) - LS-C201544 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Jurkat. ATRX antibody dilution 1.0 ug/ml.

Anti-ATRX Antibody (clone 3C9) - LS-C196726 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C9
Detection limit for recombinant GST tagged ATRX is approximately 0.1 ng/ml as a capture antibody.

Anti-ATRX Antibody (C-Terminus) - LS-C286484 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ATRX by Immunohistochemistry. Sample: FFPE section of human basal cell carcinoma. Antibody: Affinity purified rabbit anti-ATRX used at a dilution of 1:250.

ATRX Antibody - NBP1-32851 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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