| Gene Symbol |
RNF185
|
| Entrez Gene |
91445
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 185
|
| Other Description |
BSK65-MONO1|BSK65-MONO2|BSK65-PANC1|BSK65-PANC2|BSK65-TEST1|BSK65-TEST2|BSK65-TEST3|E3 ubiquitin-protein ligase RNF185
|
| Swissprots |
A8K5C1 Q96GF1 Q8N900 A9X3T8
|
| Accessions |
CAH05436 CAH05489 EAW59943 EAW59944 EAW59945 EAW59946 EAW59947 EAW59948 EAW59949 EAW59950 EAW59951 EAW59952 EAW59953 Q96GF1 AA258379 AK027035 AK075154 AK095947 BAC04659 AK291236 BAF83925 AK297414 BAG59848 BC009504 AAH09504 BC012817 AAH12817 BC017302 BC026040 AAH26040 BC033166 AAH33166 BC035684 AAH35684 BX648019 CR456349 CAG30235 CU013059 CAK54490 CU013347 CAK54789 DA498404 DB134817 DQ296559 ABB97506 DQ296560 ABB97507 DQ296561 ABB97508 DQ296562 ABB97509 DQ296563 ABB97510 DQ296564 ABB97511 DQ296565 ABB97512 XM_006724373 XP_006724436 XM_006724374 XP_006724437 NM_001135824 NM_001135825 NP_001129297 NM_152267 NP_689480 NR_024209 NR_024210 NR_024211 NR_024212
|
| Function |
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2. {ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521}.
|
| Subcellular Location |
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|