VPS29

Gene Symbol	VPS29
Entrez Gene	51699
Alt Symbol	DC15, DC7, PEP11
Species	Human
Gene Type	protein-coding
Description	vacuolar protein sorting 29 homolog (S. cerevisiae)
Other Description	PEP11 homolog|hVPS29|retromer protein|vacuolar protein sorting-associated protein 29|vacuolar sorting protein VPS29/PEP11|vesicle protein sorting 29|x 007 protein
Swissprots	Q6IAH3 Q9NRP1 Q9H0W0 Q6FIF8 Q9UBQ0 Q9NRU7 Q502Y5
Accessions	EAW97918 EAW97919 Q9UBQ0 AA148059 AB578890 AB578891 AB578892 AB618733 BAJ83889 AF086379 AF168716 AAF87318 AF175264 AAF89952 AF193795 AAF04596 AF201936 AAF86872 AF201946 AAF17238 AK000499 AK129767 AK130510 AL136614 CAB66549 AL832866 CAI46196 AM392835 CAL37713 BC000880 AAH00880 BC015095 AAH15095 BC017964 BC032462 AAH32462 BC095446 AAH95446 BF030144 BG707325 BM806646 BU568689 CB158821 CR457182 CAG33463 CR533468 CAG38499 XM_006719459 XP_006719522 XM_006719460 XP_006719523 XM_011538484 XP_011536786 XM_011538485 XP_011536787 NM_001282150 NP_001269079 NM_001282151 NP_001269080 NM_016226 NP_057310 NM_057180 NP_476528 NR_104099 NR_104100 NR_104101 NR_104102
Function	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pI
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q9QZ88}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QZ88}. Early endosome {ECO:0000305}. Late endosome {ECO:0000305}.
Tissue Specificity	Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

VPS29 CRISPR/Cas9 KO Plasmid (h) - sc-409270 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 HDR Plasmid (h) - sc-409270-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 Double Nickase Plasmid (h) - sc-409270-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 Double Nickase Plasmid (h2) - sc-409270-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 CRISPR Activation Plasmid (h) - sc-409270-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 CRISPR Activation Plasmid (h2) - sc-409270-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 Lentiviral Activation Particles (h) - sc-409270-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 Lentiviral Activation Particles (h2) - sc-409270-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPS29 siRNA (h) - sc-76903 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VPS29 shRNA Plasmid (h) - sc-76903-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VPS29 shRNA (h) Lentiviral Particles - sc-76903-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VPS29 RNAi - H00051699-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

VPS29 RNAi - H00051699-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU065121 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22716 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22716 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

VPS29 siRNA (Human) - CRH9905 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

VPS29 - MBS8202114 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human VPS29 (NM_016226.3) - SHH444916 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human VPS29(NM_016226.3) - SHL127656 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human VPS29(NM_057180.1) - SHL127674 from Creative biogene Category siRNA Species Reactivities Human

Human VPS29 siRNA - orb270407 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

VPS29 shRNA Plasmid (Human) - CHH9905 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

VPS29 miRNA 3'UTR clone - MiUTR1H-11149 from Creative biogene Species Reactivities Human

VPS29 miRNA 3'UTR clone - MiUTR1H-11150 from Creative biogene Species Reactivities Human

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