Gene Symbol | CHRM1 |
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Entrez Gene | 1128 |
Alt Symbol | HM1, M1, M1R |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, muscarinic 1 |
Other Description | acetylcholine receptor, muscarinic 1|muscarinic acetylcholine receptor M1 |
Swissprots | Q96RH1 P11229 |
Accessions | CAA33334 CAA36291 CAA68560 EAW74124 EAW74125 EAW74126 P11229 AF385587 AAK68112 AF498915 AAM18938 AJ006520 CAA07081 AK312374 BAG35292 BC007740 AAH07740 BC022984 AAH22984 BT007166 AAP35830 DQ890725 ABM81651 DQ892720 ABM83646 DQ895969 ABM86895 XM_011544742 XP_011543044 NM_000738 NP_000729 |
Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
Top Pathways | Calcium signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction |
mAChR M1 CRISPR/Cas9 KO Plasmid (h) - sc-401453 from Santa Cruz Biotechnology
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mAChR M1 HDR Plasmid (h) - sc-401453-HDR from Santa Cruz Biotechnology
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mAChR M1 Double Nickase Plasmid (h) - sc-401453-NIC from Santa Cruz Biotechnology
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mAChR M1 Double Nickase Plasmid (h2) - sc-401453-NIC-2 from Santa Cruz Biotechnology
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mAChR M1 CRISPR Activation Plasmid (h) - sc-401453-ACT from Santa Cruz Biotechnology
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mAChR M1 CRISPR Activation Plasmid (h2) - sc-401453-ACT-2 from Santa Cruz Biotechnology
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mAChR M1 Lentiviral Activation Particles (h) - sc-401453-LAC from Santa Cruz Biotechnology
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mAChR M1 Lentiviral Activation Particles (h2) - sc-401453-LAC-2 from Santa Cruz Biotechnology
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mAChR M1 siRNA (h) - sc-35829 from Santa Cruz Biotechnology
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mAChR M1 shRNA Plasmid (h) - sc-35829-SH from Santa Cruz Biotechnology
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mAChR M1 shRNA (h) Lentiviral Particles - sc-35829-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU009821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6091 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08137 from Sigma-Aldrich
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CHRM1 siRNA (Human) - CRH0805 from Cohesion Biosciences
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Muscarinic Acetylcholine Receptor M1/CHRM1 RNAi - H00001128-R02 from Novus Biologicals
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CHRM1 - MBS8223829 from MyBioSource
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mAChR M1 CRISPR/Cas9 KO Plasmid (h2) - sc-401453-KO-2 from Santa Cruz Biotechnology
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mAChR M1 HDR Plasmid (h2) - sc-401453-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CHRM1(NM_000738.2) - SHG176641 from Creative biogene
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Human CHRM1 siRNA - orb261307 from Biorbyt
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CHRM1 shRNA Plasmid (Human) - CHH0805 from Cohesion Biosciences
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CHRM1 miRNA 3'UTR clone - MiUTR1H-02136 from Creative biogene
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