NUDT4
| Gene Symbol | NUDT4 |
|---|---|
| Entrez Gene | 11163 |
| Alt Symbol | DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P |
| Species | Human |
| Gene Type | protein-coding |
| Description | nudix (nucleoside diphosphate linked moiety X)-type motif 4 |
| Other Description | DIPP-2|diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2|diphosphoinositol polyphosphate phosphohydrolase 2|diphosphoinositol polyphosphate phosphohydrolase type 2 |
| Swissprots | Q9NZK0 Q9NPC5 Q68DD7 Q9NZJ9 B7Z916 Q4AEJ6 Q9NZK1 Q53EZ2 Q9NS30 |
| Accessions | EAW97475 EAW97476 EAW97477 EAW97478 EAW97479 Q9NZJ9 AB007956 BAE16985 AF067803 AAF75563 AF191649 AAF68855 AF191650 AAF68856 AF191651 AAF68857 AF191652 AAF68858 AF191653 AAF68859 AF191654 AF191655 AK223497 BAD97217 AK304296 BAH14152 AK315778 BAG38126 BC012069 AAH12069 BC051310 AAH51310 BG777287 BM193309 BP315657 BT020109 AAV38912 BT020110 AAV38913 CB961167 CN335956 CR749445 CAH18283 DC323957 DQ786307 DQ892199 ABM83125 DQ895394 ABM86320 XM_011537794 XP_011536096 XM_011537795 XP_011536097 XM_011537796 XP_011536098 NM_001301022 NP_001287951 NM_001301023 NP_001287952 NM_001301024 NP_001287953 NM_019094 NP_061967 NM_199040 NP_950241 |
| Function | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10777568}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12121577}. |
| Tissue Specificity | Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney. {ECO:0000269|PubMed:10777568}. |
NUDT4 CRISPR/Cas9 KO Plasmid (h) - sc-409813 from Santa Cruz Biotechnology
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NUDT4 HDR Plasmid (h) - sc-409813-HDR from Santa Cruz Biotechnology
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NUDT4 Double Nickase Plasmid (h) - sc-409813-NIC from Santa Cruz Biotechnology
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NUDT4 Double Nickase Plasmid (h2) - sc-409813-NIC-2 from Santa Cruz Biotechnology
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NUDT4 CRISPR Activation Plasmid (h) - sc-409813-ACT from Santa Cruz Biotechnology
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NUDT4 CRISPR Activation Plasmid (h2) - sc-409813-ACT-2 from Santa Cruz Biotechnology
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NUDT4 Lentiviral Activation Particles (h) - sc-409813-LAC from Santa Cruz Biotechnology
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NUDT4 Lentiviral Activation Particles (h2) - sc-409813-LAC-2 from Santa Cruz Biotechnology
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NUDT4 siRNA (h) - sc-95725 from Santa Cruz Biotechnology
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NUDT4 shRNA Plasmid (h) - sc-95725-SH from Santa Cruz Biotechnology
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NUDT4 shRNA (h) Lentiviral Particles - sc-95725-V from Santa Cruz Biotechnology
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NUDT4 RNAi - H00011163-R04 from Novus Biologicals
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NUDT4 RNAi - H00011163-R03 from Novus Biologicals
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MISSION® esiRNA - EHU114091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15603 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15603 from Sigma-Aldrich
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NUDT4 siRNA (Human) - CRH7644 from Cohesion Biosciences
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shRNA set against Human NUDT4 (NM_199040.2) - SHH356196 from Creative biogene
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shRNA set against Human NUDT4(NM_199040.2) - SHR026142 from Creative biogene
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shRNA set against Human NUDT4(NM_019094.4) - SHR026184 from Creative biogene
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Human NUDT4 siRNA - orb268146 from Biorbyt
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NUDT4 shRNA Plasmid (Human) - CHH7644 from Cohesion Biosciences
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NUDT4 miRNA 3'UTR clone - MiUTR1H-06971 from Creative biogene
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NUDT4 miRNA 3'UTR clone - MiUTR1H-06972 from Creative biogene
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