| Gene Symbol | RPGR |
|---|---|
| Entrez Gene | 6103 |
| Alt Symbol | COD1, CORDX1, CRD, PCDX, RP15, RP3, XLRP3, orf15 |
| Species | Human |
| Gene Type | protein-coding |
| Description | retinitis pigmentosa GTPase regulator |
| Other Description | X-linked retinitis pigmentosa GTPase regulator|retinitis pigmentosa 15|retinitis pigmentosa 3 GTPase regulator |
| Swissprots | Q92834 O00702 Q8N5T6 Q93039 E9PE28 Q9UMR1 Q3KN84 B1ARN3 Q9HD29 O00737 |
| Accessions | AAG00550 AAG00551 CAC86116 EAW59441 EAW59442 EAW59443 EAW59444 Q92834 AJ238395 CAB54002 AK223491 BAD97211 AK291832 BAF84521 AY927527 BC031624 AAH31624 BK005711 DAA05713 BP233620 BX644678 CA313540 DQ426891 DQ980616 DQ980617 JF432801 ADZ16018 U57629 AAC50481 X97668 CAA66258 XM_005272633 XP_005272690 XM_011543940 XP_011542242 NM_000328 NP_000319 NM_001034853 NP_001030025 NM_001023582 |
| Function | Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia. {ECO:0000250, ECO:0000269|PubMed:21933838}. |
| Subcellular Location | Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9R0X5}. Golgi apparatus {ECO:0000269|PubMed:15772089}. |
| Tissue Specificity | Heart, brain, placenta, lung, liver, muscle, kidney, retina, pancreas and fetal retinal pigment epithelium. Isoform 3 is found only in the retina. Colocalizes with RPGRIP1 in the outer segment of rod photoreceptors and cone outer segments. {ECO:0000269|PubMed:12140192}. |
RPGR CRISPR/Cas9 KO Plasmid (h) - sc-404441 from Santa Cruz Biotechnology
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RPGR HDR Plasmid (h) - sc-404441-HDR from Santa Cruz Biotechnology
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RPGR Double Nickase Plasmid (h) - sc-404441-NIC from Santa Cruz Biotechnology
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RPGR Double Nickase Plasmid (h2) - sc-404441-NIC-2 from Santa Cruz Biotechnology
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RPGR CRISPR Activation Plasmid (h) - sc-404441-ACT from Santa Cruz Biotechnology
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RPGR CRISPR Activation Plasmid (h2) - sc-404441-ACT-2 from Santa Cruz Biotechnology
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RPGR Lentiviral Activation Particles (h) - sc-404441-LAC from Santa Cruz Biotechnology
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RPGR Lentiviral Activation Particles (h2) - sc-404441-LAC-2 from Santa Cruz Biotechnology
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RPGR siRNA (h) - sc-41895 from Santa Cruz Biotechnology
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RPGR shRNA Plasmid (h) - sc-41895-SH from Santa Cruz Biotechnology
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RPGR shRNA (h) Lentiviral Particles - sc-41895-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU062581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18527 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18527 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07956 from Sigma-Aldrich
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RPGR siRNA (Human) - CRH4110 from Cohesion Biosciences
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RPGR - MBS8240781 from MyBioSource
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shRNA set against Human RPGR (NM_000328.2) - SHH397980 from Creative biogene
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shRNA set against Human RPGR(NM_001034853.1) - SHR188094 from Creative biogene
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RPGR shRNA Plasmid (Human) - CHH4110 from Cohesion Biosciences
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RPGR miRNA 3'UTR clone - MiUTR1H-08969 from Creative biogene
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RPGR miRNA 3'UTR clone - MiUTR1H-08970 from Creative biogene
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