PPP1CA

Gene Symbol	PPP1CA
Entrez Gene	5499
Alt Symbol	PP-1A, PP1A, PP1alpha, PPP1A
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, catalytic subunit, alpha isozyme
Other Description	protein phosphatase 1, catalytic subunit, alpha isoform|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit|serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Swissprots	B2R908 P62136 Q07161 A6NNR3
Accessions	BAH56195 BAH69083 BAH69084 EAW74607 EAW74608 EAW74609 EAW74610 P62136 AK098311 AK127616 BAG54534 AK313586 BAG36355 AL557336 BC001888 AAH01888 BC004482 AAH04482 BC008010 AAH08010 BE278068 BE793459 BF526659 BG480286 BM799599 BM982080 BT006629 AAP35275 J04759 AAA36475 M63960 AAA36508 S57501 AAB26015 X70848 CAA50197 NM_001008709 NP_001008709 NM_002708 NP_002699 NM_206873 NP_996756
Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways	Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPP1CA-Over-expression-Lysate - LY10537a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PPP1CA overexpression lysate - LY400954 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PPP1CA overexpression lysate - LY423356 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PPP1CA 293 Cell Lysate - 409917 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PPP1CA 293 Cell Lysate - 403288 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PPP1CA 293 Cell Lysate - 400897 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PP1 alpha/PPP1A Overexpression Lysate (Native) - NBL1-14670 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PPP1CA Over-expression Lysate Product - GWB-FC027B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PPP1CA Over-expression Lysate Product - GWB-8C47B0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PPP1CA Over-expression Lysate Product - GWB-6BC89F from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PP1 alpha/PPP1A Overexpression Lysate (Native) - NBP2-10998 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human PPP1CA Knockdown Stable Cell Line - CSC-DC012226 from Creative biogene Category Cell Line Species Human

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