PPP1CA

Gene Symbol	PPP1CA
Entrez Gene	5499
Alt Symbol	PP-1A, PP1A, PP1alpha, PPP1A
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, catalytic subunit, alpha isozyme
Other Description	protein phosphatase 1, catalytic subunit, alpha isoform|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit|serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Swissprots	B2R908 P62136 Q07161 A6NNR3
Accessions	BAH56195 BAH69083 BAH69084 EAW74607 EAW74608 EAW74609 EAW74610 P62136 AK098311 AK127616 BAG54534 AK313586 BAG36355 AL557336 BC001888 AAH01888 BC004482 AAH04482 BC008010 AAH08010 BE278068 BE793459 BF526659 BG480286 BM799599 BM982080 BT006629 AAP35275 J04759 AAA36475 M63960 AAA36508 S57501 AAB26015 X70848 CAA50197 NM_001008709 NP_001008709 NM_002708 NP_002699 NM_206873 NP_996756
Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways	Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PP1α siRNA I - 13319 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

PP1α CRISPR/Cas9 KO Plasmid (h) - sc-400318 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α HDR Plasmid (h) - sc-400318-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α Double Nickase Plasmid (h) - sc-400318-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α Double Nickase Plasmid (h2) - sc-400318-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α CRISPR Activation Plasmid (h) - sc-400318-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α CRISPR Activation Plasmid (h2) - sc-400318-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α Lentiviral Activation Particles (h) - sc-400318-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α Lentiviral Activation Particles (h2) - sc-400318-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1α siRNA (h) - sc-36299 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP1å shRNA Plasmid (h) - sc-36299-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP1å shRNA (h) Lentiviral Particles - sc-36299-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

pan PP1 siRNA (h) - sc-43545 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

pan PP1 shRNA Plasmid (h) - sc-43545-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

pan PP1 shRNA (h) Lentiviral Particles - sc-43545-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP1 alpha/PPP1A RNAi - H00005499-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PP1 alpha/PPP1A RNAi - H00005499-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU062511 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® Human Phosphatase - SIHP0511 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0512 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0513 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17254 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17254 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02630 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02630

PPP1CA siRNA (Human) - CRH3684 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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