| Gene Symbol |
TRIM39
|
| Entrez Gene |
56658
|
| Alt Symbol |
RNF23, TFP, TRIM39B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 39
|
| Other Description |
E3 ubiquitin-protein ligase TRIM39|ring finger protein 23|testis-abundant finger protein|tripartite motif-containing 39|tripartite motif-containing protein 39
|
| Swissprots |
Q96IB6 Q76BL3 Q9HCM9 Q5STG3 Q8IYT9 Q5STG4
|
| Accessions |
BAD13703 BAD13704 BAE78608 EAX03283 EAX03284 EAX03285 EAX03286 Q9HCM9 AB046381 BAB16374 AI159923 AK292512 BAF85201 AX776007 CAE11703 BC007661 AAH07661 BC034985 AAH34985 BT007370 AAP36034 DB071507 NM_021253 NP_067076 NM_172016 NP_742013
|
| Function |
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:22529100}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion {ECO:0000269|PubMed:19100260}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1.
|
| Tissue Specificity |
Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis. {ECO:0000269|PubMed:19100260}.
|
![Western Blot: RNF23 Overexpression Lysate (Adult Normal) [NBL1-17295] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF23.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12025_RNF23%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17295-img0002.jpg)