| Gene Symbol |
NEDD4
|
| Entrez Gene |
4734
|
| Alt Symbol |
NEDD4-1, RPF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase NEDD4|cell proliferation-inducing gene 53 protein|neural precursor cell expressed developmentally down-regulated protein 4|receptor-potentiating factor 1
|
| Swissprots |
P46934 D6RF89 B7ZM59 B4E2R7 B7ZM60 B9EGN5 A1KY35 A6ND72 A7MD29
|
| Accessions |
EAW77495 EAW77496 EAW77497 P46934 AK304394 BAG65229 AK307541 AL832063 AL832359 AL833293 AL833300 AY550969 AAT52215 BC035707 BC047035 BC136605 AAI36606 BC144284 AAI44285 BC144285 AAI44286 BC152452 AAI52453 BC152562 AAI52563 D42055 BAA07655 DB451823 EU832821 ACE87832 GQ129222 ACT64356 XM_011521624 XP_011519926 XM_011521625 XP_011519927 XM_011521626 XP_011519928 XM_011521627 XP_011519929 NM_001284338 NP_001271267 NM_001284339 NP_001271268 NM_001284340 NP_001271269 NM_006154 NP_006145 NM_198400 NP_940682 NR_104302
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR- 2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of E
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1. {ECO:0000250, ECO:0000269|PubMed:18819914}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Endocytosis, Epstein-Barr virus infection
|