| Gene Symbol |
NIPAL4
|
| Entrez Gene |
348938
|
| Alt Symbol |
ARCI6, ICHTHYIN, ICHYN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIPA-like domain containing 4
|
| Other Description |
NIPA-like protein 4|magnesium transporter NIPA4|non-imprinted in Prader-Willi/Angelman syndrome region protein 4
|
| Swissprots |
Q0D2J9 A8S6F8 Q0D2K0 A8S6F5 Q0D2J8 B4DLF3 A8S6F1
|
| Accessions |
ABW69628 ABW69629 ABW69630 EAW61600 Q0D2K0 AF131815 AK026158 AK296972 BAG59515 AK308830 AK309242 BC105708 AAI05709 BC105709 AAI05710 BC105710 AAI05711 BC160182 AAI60182 DB153698 DC348015 XM_011534552 XP_011532854 NM_001099287 NP_001092757 NM_001172292 NP_001165763
|
| Function |
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. {ECO:0000250, ECO:0000269|PubMed:15317751}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues tested except liver, thyroid and fetal brain. {ECO:0000269|PubMed:15317751, ECO:0000269|PubMed:17557927}.
|