Gene Symbol | NIPAL4 |
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Entrez Gene | 348938 |
Alt Symbol | ARCI6, ICHTHYIN, ICHYN |
Species | Human |
Gene Type | protein-coding |
Description | NIPA-like domain containing 4 |
Other Description | NIPA-like protein 4|magnesium transporter NIPA4|non-imprinted in Prader-Willi/Angelman syndrome region protein 4 |
Swissprots | Q0D2J9 A8S6F8 Q0D2K0 A8S6F5 Q0D2J8 B4DLF3 A8S6F1 |
Accessions | ABW69628 ABW69629 ABW69630 EAW61600 Q0D2K0 AF131815 AK026158 AK296972 BAG59515 AK308830 AK309242 BC105708 AAI05709 BC105709 AAI05710 BC105710 AAI05711 BC160182 AAI60182 DB153698 DC348015 XM_011534552 XP_011532854 NM_001099287 NP_001092757 NM_001172292 NP_001165763 |
Function | Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. {ECO:0000250, ECO:0000269|PubMed:15317751}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues tested except liver, thyroid and fetal brain. {ECO:0000269|PubMed:15317751, ECO:0000269|PubMed:17557927}. |
Ichthyin CRISPR/Cas9 KO Plasmid (h) - sc-406427 from Santa Cruz Biotechnology
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Ichthyin HDR Plasmid (h) - sc-406427-HDR from Santa Cruz Biotechnology
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Ichthyin Double Nickase Plasmid (h) - sc-406427-NIC from Santa Cruz Biotechnology
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Ichthyin Double Nickase Plasmid (h2) - sc-406427-NIC-2 from Santa Cruz Biotechnology
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Ichthyin CRISPR Activation Plasmid (h) - sc-406427-ACT from Santa Cruz Biotechnology
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Ichthyin CRISPR Activation Plasmid (h2) - sc-406427-ACT-2 from Santa Cruz Biotechnology
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Ichthyin Lentiviral Activation Particles (h) - sc-406427-LAC from Santa Cruz Biotechnology
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Ichthyin Lentiviral Activation Particles (h2) - sc-406427-LAC-2 from Santa Cruz Biotechnology
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Ichthyin siRNA (h) - sc-91664 from Santa Cruz Biotechnology
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Ichthyin shRNA Plasmid (h) - sc-91664-SH from Santa Cruz Biotechnology
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Ichthyin shRNA (h) Lentiviral Particles - sc-91664-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15305 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15305 from Sigma-Aldrich
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NIPAL4 siRNA (Human) - CRJ7544 from Cohesion Biosciences
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shRNA set against Human NIPAL4 (NM_001099287.1) - SHH352532 from Creative biogene
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Human NIPAL4 siRNA - orb278045 from Biorbyt
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NIPAL4 shRNA Plasmid (Human) - CHJ7544 from Cohesion Biosciences
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NIPAL4 miRNA 3'UTR clone - MiUTR1H-04781 from Creative biogene
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