| Gene Symbol |
FBXO43
|
| Entrez Gene |
286151
|
| Alt Symbol |
EMI2, ERP1, FBX43
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 43
|
| Other Description |
F-box only protein 43|early mitotic inhibitor 2|endogenous meiotic inhibitor 2
|
| Swissprots |
Q4G163
|
| Accessions |
Q4G163 AI198884 AK310518 BC028709 BC090892 BC156850 AAI56851 BG391951 DA996924 DB056068 DB088246 XM_011516987 XP_011515289 XM_011516988 XP_011515290 XM_011516989 XP_011515291 XM_011516990 XP_011515292 XM_011516991 XP_011515293 XM_011516992 XP_011515294 XR_928320 NM_001077528 NM_001029860 NP_001025031 NR_036491
|
| Function |
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). {ECO:0000305}.
|
| Top Pathways |
Oocyte meiosis
|