Gene Symbol | FBXO43 |
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Entrez Gene | 286151 |
Alt Symbol | EMI2, ERP1, FBX43 |
Species | Human |
Gene Type | protein-coding |
Description | F-box protein 43 |
Other Description | F-box only protein 43|early mitotic inhibitor 2|endogenous meiotic inhibitor 2 |
Swissprots | Q4G163 |
Accessions | Q4G163 AI198884 AK310518 BC028709 BC090892 BC156850 AAI56851 BG391951 DA996924 DB056068 DB088246 XM_011516987 XP_011515289 XM_011516988 XP_011515290 XM_011516989 XP_011515291 XM_011516990 XP_011515292 XM_011516991 XP_011515293 XM_011516992 XP_011515294 XR_928320 NM_001077528 NM_001029860 NP_001025031 NR_036491 |
Function | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). {ECO:0000305}. |
Top Pathways | Oocyte meiosis |
Emi2 CRISPR/Cas9 KO Plasmid (h) - sc-405054 from Santa Cruz Biotechnology
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Emi2 HDR Plasmid (h) - sc-405054-HDR from Santa Cruz Biotechnology
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Emi2 Double Nickase Plasmid (h) - sc-405054-NIC from Santa Cruz Biotechnology
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Emi2 Double Nickase Plasmid (h2) - sc-405054-NIC-2 from Santa Cruz Biotechnology
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Emi2 CRISPR Activation Plasmid (h) - sc-405054-ACT from Santa Cruz Biotechnology
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Emi2 CRISPR Activation Plasmid (h2) - sc-405054-ACT-2 from Santa Cruz Biotechnology
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Emi2 Lentiviral Activation Particles (h) - sc-405054-LAC from Santa Cruz Biotechnology
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Emi2 Lentiviral Activation Particles (h2) - sc-405054-LAC-2 from Santa Cruz Biotechnology
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Emi2 siRNA (h) - sc-77268 from Santa Cruz Biotechnology
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Emi2 shRNA Plasmid (h) - sc-77268-SH from Santa Cruz Biotechnology
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Emi2 shRNA (h) Lentiviral Particles - sc-77268-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8559 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8559 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03125 from Sigma-Aldrich
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FBXO43 siRNA (Human) - CRJ7154 from Cohesion Biosciences
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FBXO43 - MBS8232402 from MyBioSource
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shRNA set against Human FBXO43 (NM_001029860.3) - SHH293329 from Creative biogene
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Human FBXO43 siRNA - orb277655 from Biorbyt
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FBXO43 shRNA Plasmid (Human) - CHJ7154 from Cohesion Biosciences
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