Gene Symbol | VPS37B |
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Entrez Gene | 79720 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | vacuolar protein sorting 37 homolog B (S. cerevisiae) |
Other Description | ESCRT-I complex subunit VPS37B|hVps37B|vacuolar protein sorting 37B|vacuolar protein sorting-associated protein 37B |
Swissprots | Q9H9H4 |
Accessions | EAW98348 EAW98349 EAW98350 EAW98351 Q9H9H4 AK022812 BAB14255 BC005882 AAH05882 BU629695 XM_005253622 XP_005253679 XM_006719602 XP_006719665 XM_011538742 XP_011537044 XM_011538743 XP_011537045 XM_011538744 XP_011537046 XM_011538745 XP_011537047 XM_011538746 XP_011537048 NM_024667 NP_078943 |
Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}. |
Subcellular Location | Late endosome membrane {ECO:0000269|PubMed:15218037}; Peripheral membrane protein {ECO:0000269|PubMed:15218037}. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion. |
Tissue Specificity | Widely expressed. Expressed in macrophages and lymphocytes. {ECO:0000269|PubMed:15218037}. |
Top Pathways | Endocytosis |
VPS37B CRISPR/Cas9 KO Plasmid (h) - sc-405821 from Santa Cruz Biotechnology
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VPS37B HDR Plasmid (h) - sc-405821-HDR from Santa Cruz Biotechnology
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VPS37B Double Nickase Plasmid (h) - sc-405821-NIC from Santa Cruz Biotechnology
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VPS37B Double Nickase Plasmid (h2) - sc-405821-NIC-2 from Santa Cruz Biotechnology
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VPS37B CRISPR Activation Plasmid (h) - sc-405821-ACT from Santa Cruz Biotechnology
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VPS37B CRISPR Activation Plasmid (h2) - sc-405821-ACT-2 from Santa Cruz Biotechnology
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VPS37B Lentiviral Activation Particles (h) - sc-405821-LAC from Santa Cruz Biotechnology
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VPS37B Lentiviral Activation Particles (h2) - sc-405821-LAC-2 from Santa Cruz Biotechnology
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VPS37B siRNA (h) - sc-95762 from Santa Cruz Biotechnology
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VPS37B shRNA Plasmid (h) - sc-95762-SH from Santa Cruz Biotechnology
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VPS37B shRNA (h) Lentiviral Particles - sc-95762-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU054721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22722 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22722 from Sigma-Aldrich
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VPS37B siRNA (Human) - CRJ2513 from Cohesion Biosciences
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VPS37B - MBS8232497 from MyBioSource
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shRNA set against Human VPS37B (NM_024667.2) - SHH444988 from Creative biogene
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Human VPS37B siRNA - orb273014 from Biorbyt
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VPS37B shRNA Plasmid (Human) - CHJ2513 from Cohesion Biosciences
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VPS37B miRNA 3'UTR clone - MiUTR3H-10981 from Creative biogene
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