| Gene Symbol | TLR1 |
|---|---|
| Entrez Gene | 7096 |
| Alt Symbol | CD281, TIL, TIL. LPRS5, rsc786 |
| Species | Human |
| Gene Type | protein-coding |
| Description | toll-like receptor 1 |
| Other Description | toll/interleukin-1 receptor-like protein |
| Swissprots | Q15399 Q9UG90 D1CS41 Q32MK3 Q32MK4 O15452 D1CS39 |
| Accessions | EAW92901 Q15399 AB445617 BAG55014 AK292982 BAF85671 AL050262 CAB43364 AW408740 BC089403 AAH89403 BC109093 AAI09094 BC109094 AAI09095 BU623316 CR533562 CAG38593 D13637 BAA02801 DQ012254 AAY85633 DQ012255 AAY85634 DQ012256 AAY85635 DQ012257 AAY85636 DQ012258 AAY85637 DQ012259 AAY85638 DQ012260 AAY85639 DQ012261 AAY85640 DQ012262 AAY85641 DQ012263 AAY85642 DQ012264 AAY85643 U88540 AAC34137 XM_005262662 XP_005262719 XM_006714028 XP_006714091 XM_011513742 XP_011512044 XM_011513743 XP_011512045 XM_011513744 XP_011512046 XM_011513745 XP_011512047 XR_925162 XR_925163 XR_925165 NM_003263 NP_003254 |
| Function | Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. |
| Top Pathways | Toll-like receptor signaling pathway, Tuberculosis |
TLR1 CRISPR/Cas9 KO Plasmid (h) - sc-402458 from Santa Cruz Biotechnology
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TLR1 HDR Plasmid (h) - sc-402458-HDR from Santa Cruz Biotechnology
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TLR1 Double Nickase Plasmid (h) - sc-402458-NIC from Santa Cruz Biotechnology
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TLR1 Double Nickase Plasmid (h2) - sc-402458-NIC-2 from Santa Cruz Biotechnology
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TLR1 CRISPR Activation Plasmid (h) - sc-402458-ACT from Santa Cruz Biotechnology
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TLR1 CRISPR Activation Plasmid (h2) - sc-402458-ACT-2 from Santa Cruz Biotechnology
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TLR1 Lentiviral Activation Particles (h) - sc-402458-LAC from Santa Cruz Biotechnology
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TLR1 Lentiviral Activation Particles (h2) - sc-402458-LAC-2 from Santa Cruz Biotechnology
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TLR1 siRNA (h) - sc-40254 from Santa Cruz Biotechnology
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TLR1 shRNA Plasmid (h) - sc-40254-SH from Santa Cruz Biotechnology
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TLR1 shRNA (h) Lentiviral Particles - sc-40254-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU117701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21399 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21399 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00491 from Sigma-Aldrich
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TLR1 siRNA (Human) - CRH4863 from Cohesion Biosciences
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TLR1 RNAi - H00007096-R02 from Novus Biologicals
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TLR1 - MBS8221544 from MyBioSource
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shRNA set against Human TLR1 (NM_003263.3) - SHH427920 from Creative biogene
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shRNA set against Human TLR1(NM_003263.3) - SHL072988 from Creative biogene
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TLR1 shRNA Plasmid (Human) - CHH4863 from Cohesion Biosciences
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TLR1 miRNA 3'UTR clone - MiUTR1H-10433 from Creative biogene
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