NLRP6
| Gene Symbol | NLRP6 |
|---|---|
| Entrez Gene | 171389 |
| Alt Symbol | AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NLR family, pyrin domain containing 6 |
| Other Description | NACHT, LRR and PYD containing protein 6|NACHT, LRR and PYD domains-containing protein 6|NACHT, leucine rich repeat and PYD containing 6|PYRIN-containing APAF1-like protein 5|angiotensin II/vasopressin receptor|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 |
| Swissprots | E9PJZ8 A8K9F3 P59044 |
| Accessions | EAW61233 P59044 AF479748 AAL87105 AK292668 BAF85357 AY154461 AAO18157 CD636365 XM_011519931 XP_011518233 XR_930848 NM_001276700 NP_001263629 NM_138329 NP_612202 |
| Function | May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}. Nucleus membrane {ECO:0000250}. |
| Tissue Specificity | Highly expressed in granulocytes. Detected at much lower levels in T-cells. |
NALP6 (A-20) - sc-50632 from Santa Cruz Biotechnology
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NALP6 (F-20) - sc-50636 from Santa Cruz Biotechnology
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NALP6 (H-55) - sc-292070 from Santa Cruz Biotechnology
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Anti-NALP6 antibody - ab198798 from Abcam
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Anti-NALP6 antibody - ab116007 from Abcam
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Anti-NALP6 antibody - C-terminal - ab189536 from Abcam
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Anti-NALP6 / NLRP6 Antibody (C-Terminus) - LS-C46901 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa166-183) - LS-C148970 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa168-197, Biotin) - LS-C238087 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa168-197, FITC) - LS-C238088 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa168-197, PE) - LS-C238090 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa343-372, AP) - LS-C246625 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa343-372, APC) - LS-C246626 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa343-372, Biotin) - LS-C246627 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa343-372, FITC) - LS-C246628 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa168-197, AP) - LS-C246630 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa343-372, PE) - LS-C246629 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa168-197, APC) - LS-C246631 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa343-372, Azide-free, HRP) - LS-C248930 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa168-197, Azide-free, HRP) - LS-C248931 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa342-372) - LS-C323373 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa167-197) - LS-C323375 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa168-197) - LS-C162912 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (aa343-372) - LS-C164505 from LifeSpan Bioscience
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Anti-NALP6 / NLRP6 Antibody (N-Terminus) - LS-C115898 from LifeSpan Bioscience
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