| Gene Symbol | NLRP6 |
|---|---|
| Entrez Gene | 171389 |
| Alt Symbol | AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NLR family, pyrin domain containing 6 |
| Other Description | NACHT, LRR and PYD containing protein 6|NACHT, LRR and PYD domains-containing protein 6|NACHT, leucine rich repeat and PYD containing 6|PYRIN-containing APAF1-like protein 5|angiotensin II/vasopressin receptor|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 |
| Swissprots | E9PJZ8 A8K9F3 P59044 |
| Accessions | EAW61233 P59044 AF479748 AAL87105 AK292668 BAF85357 AY154461 AAO18157 CD636365 XM_011519931 XP_011518233 XR_930848 NM_001276700 NP_001263629 NM_138329 NP_612202 |
| Function | May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}. Nucleus membrane {ECO:0000250}. |
| Tissue Specificity | Highly expressed in granulocytes. Detected at much lower levels in T-cells. |
NALP6 CRISPR/Cas9 KO Plasmid (h) - sc-404548 from Santa Cruz Biotechnology
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NALP6 HDR Plasmid (h) - sc-404548-HDR from Santa Cruz Biotechnology
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NALP6 Double Nickase Plasmid (h) - sc-404548-NIC from Santa Cruz Biotechnology
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NALP6 Double Nickase Plasmid (h2) - sc-404548-NIC-2 from Santa Cruz Biotechnology
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NALP6 CRISPR Activation Plasmid (h) - sc-404548-ACT from Santa Cruz Biotechnology
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NALP6 CRISPR Activation Plasmid (h2) - sc-404548-ACT-2 from Santa Cruz Biotechnology
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NALP6 Lentiviral Activation Particles (h) - sc-404548-LAC from Santa Cruz Biotechnology
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NALP6 Lentiviral Activation Particles (h2) - sc-404548-LAC-2 from Santa Cruz Biotechnology
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NALP6 siRNA (h) - sc-61147 from Santa Cruz Biotechnology
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NALP6 shRNA Plasmid (h) - sc-61147-SH from Santa Cruz Biotechnology
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NALP6 shRNA (h) Lentiviral Particles - sc-61147-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN15358 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15358 from Sigma-Aldrich
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NLRP6 siRNA (Human) - CRJ6140 from Cohesion Biosciences
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NALP6 CRISPR/Cas9 KO Plasmid (h2) - sc-404548-KO-2 from Santa Cruz Biotechnology
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NALP6 HDR Plasmid (h2) - sc-404548-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Nlrp6 (NM_138329.1) - SHH353032 from Creative biogene
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shRNA set against Human NLRP6(NM_138329.1) - SHR013268 from Creative biogene
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Human NLRP6 siRNA - orb276641 from Biorbyt
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NLRP6 shRNA Plasmid (Human) - CHJ6140 from Cohesion Biosciences
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NLRP6 miRNA 3'UTR clone - MiUTR1H-06803 from Creative biogene
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