| Gene Symbol |
AGPAT1
|
| Entrez Gene |
10554
|
| Alt Symbol |
1-AGPAT1, G15, LPAAT-alpha, LPAATA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
1-acylglycerol-3-phosphate O-acyltransferase 1
|
| Other Description |
1-AGP acyltransferase 1|1-AGPAT 1|1-acyl-sn-glycerol-3-phosphate acyltransferase alpha|1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase)|1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)|lysophosphatidic acid acyltransferase alpha|lysophospholipid acyltransferase
|
| Swissprots |
Q99943 Q5BL03 A2BFI5
|
| Accessions |
AAB47493 EAX03599 EAX03600 EAX03601 EAX03602 EAX03603 EAX03604 EAX03605 EAX03606 Q99943 AF007145 AAC19153 AF218034 AAG17276 AI193422 AK056346 BAG51685 AK058025 AK129818 AK299252 BAG61283 AK315950 BAH14321 BC002402 AAH02402 BC003007 AAH03007 BC004310 AAH04310 BC006818 BC090849 AAH90849 BM763275 DA529681 DB118884 U56417 AAB58775 U75971 AAB96378 Y09565 CAA70758 XM_005248805 XP_005248862 XM_005248806 XP_005248863 XM_005272761 XP_005272818 XM_005272762 XP_005272819 XM_005274829 XP_005274886 XM_005274830 XP_005274887 XM_005275073 XP_005275130 XM_005275074 XP_005275131 XM_005275203 XP_005275260 XM_005275204 XP_005275261 XM_005275337 XP_005275394 XM_005275338 XP_005275395 XM_005275504 XP_005275561 XM_005275505 XP_005275562 XM_011514234 XP_011512536 XM_011546281 XP_011544583 XM_011547171 XP_011545473 XM_011547825 XP_011546127 XM_011548005 XP_011546307 XM_011548182 XP_011546484 XM_011548377 XP_011546679 NM_006411 NP_006402 NM_032741 NP_116130
|
| Function |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269|PubMed:21873652}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:21873652}; Multi-pass membrane protein {ECO:0000269|PubMed:21873652}.
|
| Tissue Specificity |
Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver. {ECO:0000269|PubMed:21873652}.
|
| Top Pathways |
Fat digestion and absorption, Glycerolipid metabolism, Glycerophospholipid metabolism
|