| Gene Symbol |
C1QB
|
| Entrez Gene |
713
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
complement component 1, q subcomponent, B chain
|
| Other Description |
complement C1q subcomponent subunit B|complement component 1, q subcomponent, beta polypeptide|complement component C1q, B chain|complement subcomponent C1q chain B
|
| Swissprots |
Q5T959 P02746 Q96H17
|
| Accessions |
AAQ67338 EAW95019 EAW95020 EAW95021 P02746 BC008983 AAH08983 BQ711602 DQ891531 ABM82457 DQ894720 ABM85646 M36278 AAC41692 X03084 CAA26880 XM_011542059 XP_011540361 NM_000491 NP_000482
|
| Function |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection
|
