| Gene Symbol |
ESCO1
|
| Entrez Gene |
114799
|
| Alt Symbol |
A930014I12Rik, CTF, ECO1, EFO1, ESO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
establishment of sister chromatid cohesion N-acetyltransferase 1
|
| Other Description |
CTF7 homolog 1|ECO1 homolog 1|EFO1p|ESO1 homolog 1|N-acetyltransferase ESCO1|establishment factor-like protein 1|establishment of cohesion 1 homolog 1|hEFO1
|
| Swissprots |
Q69YG4 Q8N3Z5 B0YJ11 Q69YS3 Q96PX7 Q5FWF5 Q6IMD7 B0YJ12 Q8NBG2
|
| Accessions |
ACA05989 EAX01127 EAX01128 EAX01129 Q5FWF5 AB067498 BAB67804 AK090579 BAC03483 AK096746 AL832041 CAH10584 AL834200 CAH10682 BC036943 AAH36943 BC089426 AAH89426 BG492713 BK001617 DAA02068 XM_011525798 XP_011524100 XM_011525799 XP_011524101 XR_935191 NM_052911 NP_443143
|
| Function |
Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3. {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Nuclear at interphase, associated with chromosomes during mitosis.
|
| Tissue Specificity |
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle. {ECO:0000269|PubMed:14576321}.
|