| Gene Symbol |
CDT1
|
| Entrez Gene |
81620
|
| Alt Symbol |
DUP, RIS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromatin licensing and DNA replication factor 1
|
| Other Description |
DNA replication factor Cdt1|Double parked, Drosophila, homolog of
|
| Swissprots |
Q9BWM0 Q96HE6 Q96CJ5 Q96H67 Q9H211 Q86XX9 Q96GK5
|
| Accessions |
EAW66762 EAW66763 EAW66764 Q9H211 AB053172 BAB61878 AF070552 AF321125 AAG45181 BC000137 AAH00137 BC008676 AAH08676 BC008860 AAH08860 BC009410 AAH09410 BC014202 AAH14202 BC021126 AAH21126 BC049205 AAH49205 NM_030928 NP_112190
|
| Function |
Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene. {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11125146}.
|