| Gene Symbol |
Scarb1
|
| Entrez Gene |
20778
|
| Alt Symbol |
AI120173, CD36, Cd36l1, Cla-1, Cla1, D5Ertd460e, Hdlq1, Hlb398, SR-B1, SR-BI, SRBI, Srb1, mSR-BI
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
scavenger receptor class B, member 1
|
| Other Description |
HDL QTL 1|scavenger receptor class B member 1|scavenger receptor class B type I|scavenger receptor class B1
|
| Swissprots |
Q9CWJ7 Q61009
|
| Accessions |
EDL19562 EDL19563 Q61009 AK010622 BAB27068 AK028191 BAC25802 AK033114 BAC28157 AK080894 BAC38067 AK143368 AK145588 AK154933 BAE32934 AK158122 BAE34368 AK169906 BAE41449 AK171602 AK185019 AK187730 AK189473 AK196382 AK197937 AK199031 AK201170 AK202996 AK204897 AK212899 BC004656 AAH04656 BQ176029 BY018765 CT010222 CAJ18430 U37799 AAC52378 XM_006504285 XP_006504348 XM_006504286 XP_006504349 NM_001205082 NP_001192011 NM_001205083 NP_001192012 NM_016741 NP_058021
|
| Function |
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. {ECO:0000250}.
|
| Tissue Specificity |
Expressed primarily in liver and non-placental steroidogenic tissues.
|
| Top Pathways |
Phagosome, Hepatitis C, Bile secretion, Fat digestion and absorption, Vitamin digestion and absorption
|