| Gene Symbol |
CTDSP2
|
| Entrez Gene |
10106
|
| Alt Symbol |
OS4, PSR2, SCP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
|
| Other Description |
NLI-interacting factor 2|carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2|conserved gene amplified in osteosarcoma|nuclear LIM interactor-interacting factor 2|protein OS-4|small C-terminal domain phosphatase 2|small CTD phosphatase 2
|
| Swissprots |
Q6NZY3 Q53ZR2 A8K5H4 O14595 Q9UEX1
|
| Accessions |
EAW97081 EAW97082 EAW97083 EAW97084 EAW97085 EAW97086 EAW97087 EAW97088 EAW97089 O14595 AF000152 AAB71816 AF022231 AAD09331 AK226076 AK291289 BAF83978 AK294930 BAG58009 AK310183 AK310873 AK311070 AK312413 AY279531 AAP34399 BC018922 BC065920 AAH65920 CN313995 DB001093 HQ448049 ADQ32530 U81556 AAB39318 XM_005268556 XP_005268613 NM_005730 NP_005721
|
| Function |
Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver. {ECO:0000269|PubMed:15681389}.
|
