| Gene Symbol | DCUN1D1 |
|---|---|
| Entrez Gene | 54165 |
| Alt Symbol | DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DCN1, defective in cullin neddylation 1, domain containing 1 |
| Other Description | DCN1-like protein 1|DCUN1 domain-containing protein 1|RP42 homolog|defective in cullin neddylation protein 1-like protein 1|squamous cell carcinoma related oncogene|squamous cell carcinoma-related oncogene |
| Swissprots | Q9HCT3 Q8TEX7 Q9H6M1 Q7L3G9 Q96GG9 B2RB37 |
| Accessions | CAJ01275 CAJ42719 CCA61624 CDM22108 EAW78341 EAW78342 EAW78343 Q96GG9 AF292100 AAG00606 AF456425 AAL78672 AF456426 AAL78673 AK025764 BAB15235 AK056335 BAG51680 AK095773 AK297328 BAG59788 AK314480 BAG37084 AW103206 BC009478 AAH09478 BC013163 AAH13163 BI828039 BU620603 CD687300 HQ448015 ADQ32496 HY031019 HY052047 XM_005247539 XP_005247596 XM_011512912 XP_011511214 XM_011512913 XP_011511215 XM_011512914 XP_011511216 XM_011512915 XP_011511217 XM_011512916 XP_011511218 NM_001308101 NP_001295030 NM_020640 NP_065691 |
| Function | Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas. {ECO:0000269|PubMed:10777668}. |