Gene Symbol |
FUOM
|
Entrez Gene |
282969
|
Alt Symbol |
C10orf125, FUCU, FucM
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
fucose mutarotase
|
Other Description |
protein fucU homolog
|
Swissprots |
Q5VWY2 A1L300 A2VDF0 Q6ZPD2 Q5VWY3
|
Accessions |
A2VDF0 EAW61337 EAW61338 AI333356 AK129527 BAC85178 AK310070 BC129818 AAI29819 BC129819 AAI29820 BM009909 BU849497 BX119427 CN368132 HY163253 XM_011539670 XP_011537972 XM_011539671 XP_011537973 XM_011539672 XP_011537974 XM_011539673 XP_011537975 XM_011539674 XP_011537976 XM_011539675 XP_011537977 NM_001098483 NP_001091953 NM_001301827 NP_001288756 NM_001301828 NP_001288757 NM_198472 NP_940874
|
Function |
Involved in the interconversion between alpha- and beta- L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O- glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. {ECO:0000269|PubMed:17602138}.
|