H2AFV
| Gene Symbol | H2AFV |
|---|---|
| Entrez Gene | 94239 |
| Alt Symbol | H2A.Z-2, H2AV |
| Species | Human |
| Gene Type | protein-coding |
| Description | H2A histone family, member V |
| Other Description | H2A.F/Z|histone H2A.F/Z|histone H2A.V|purine-rich binding element protein B |
| Swissprots | Q59GV8 A6NFA8 Q6PK98 A8MQC5 A6NKY0 A6NN01 Q71UI9 |
| Accessions | AAS00365 EAW61074 EAW61075 EAW61076 EAW61077 Q71UI9 AB209001 BAD92238 AF081192 AAC31938 AK023973 BAG51243 AK025785 AK129989 AL049324 AL520785 AL520811 BC000098 AAH00098 BC004274 AAH04274 BC014885 AAH14885 BC070169 AAH70169 BF242439 BG679983 BG754026 BG773256 BI257891 BM452844 BM453663 BM850777 BX644511 CB148943 DA456475 DB460745 DQ892406 ABM83332 DQ895618 ABM86544 NM_012412 NP_036544 NM_138635 NP_619541 NM_201436 NP_958844 NM_201516 NP_958924 NM_201517 NP_958925 |
| Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. |
| Top Pathways | Systemic lupus erythematosus, Alcoholism |
Histone H2A.F/Z CRISPR/Cas9 KO Plasmid (h) - sc-410631 from Santa Cruz Biotechnology
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Histone H2A.F/Z HDR Plasmid (h) - sc-410631-HDR from Santa Cruz Biotechnology
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Histone H2A.F/Z Double Nickase Plasmid (h) - sc-410631-NIC from Santa Cruz Biotechnology
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Histone H2A.F/Z Double Nickase Plasmid (h2) - sc-410631-NIC-2 from Santa Cruz Biotechnology
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Histone H2A.F/Z CRISPR Activation Plasmid (h) - sc-410631-ACT from Santa Cruz Biotechnology
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Histone H2A.F/Z CRISPR Activation Plasmid (h2) - sc-410631-ACT-2 from Santa Cruz Biotechnology
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Histone H2A.F/Z Lentiviral Activation Particles (h) - sc-410631-LAC from Santa Cruz Biotechnology
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Histone H2A.F/Z Lentiviral Activation Particles (h2) - sc-410631-LAC-2 from Santa Cruz Biotechnology
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Histone H2A.F/Z siRNA (h) - sc-105520 from Santa Cruz Biotechnology
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Histone H2A.F/Z shRNA Plasmid (h) - sc-105520-SH from Santa Cruz Biotechnology
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Histone H2A.F/Z shRNA (h) Lentiviral Particles - sc-105520-V from Santa Cruz Biotechnology
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H2AFV RNAi - H00094239-R02 from Novus Biologicals
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H2AFV RNAi - H00094239-R04 from Novus Biologicals
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H2AFV RNAi - H00094239-R05 from Novus Biologicals
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H2AFV RNAi - H00094239-R01 from Novus Biologicals
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MISSION® esiRNA - EHU114011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9840 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9840 from Sigma-Aldrich
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H2AFV siRNA (Human) - CRJ4262 from Cohesion Biosciences
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H2AFV RNAi - H00094239-R03 from Novus Biologicals
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H2AFV - MBS8224044 from MyBioSource
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shRNA set against Human H2AFV(NM_201436.2) - SHH112097 from Creative biogene
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shRNA set against Human H2AFV(NM_012412.4) - SHH112099 from Creative biogene
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shRNA set against Human H2AFV(NM_201516.2) - SHH112117 from Creative biogene
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shRNA set against Human H2AFV(NM_201517.2) - SHH112135 from Creative biogene
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