Gene Symbol | POP7 |
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Entrez Gene | 10248 |
Alt Symbol | 0610037N12Rik, RPP2, RPP20 |
Species | Human |
Gene Type | protein-coding |
Description | processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) |
Other Description | POP7 (processing of precursor, S. cerevisiae) homolog|RNaseP protein p20|hPOP7|processing of precursor 7, ribonuclease P subunit|ribonuclease P protein subunit p20|ribonucleases P/MRP protein subunit POP7 homolog |
Swissprots | A4D2E0 O75817 Q9BV74 |
Accessions | EAL23821 EAW76495 O75817 AJ572668 BC001430 AAH01430 BI666854 U94316 AAC24113 NM_005837 NP_005828 |
Function | Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:14715275}. Cytoplasm {ECO:0000269|PubMed:14715275}. Cytoplasmic granule {ECO:0000269|PubMed:14715275}. Note=Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules. |
Top Pathways | RNA transport, Ribosome biogenesis in eukaryotes |
Rpp20 CRISPR/Cas9 KO Plasmid (h) - sc-410558 from Santa Cruz Biotechnology
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Rpp20 HDR Plasmid (h) - sc-410558-HDR from Santa Cruz Biotechnology
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Rpp20 Double Nickase Plasmid (h) - sc-410558-NIC from Santa Cruz Biotechnology
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Rpp20 Double Nickase Plasmid (h2) - sc-410558-NIC-2 from Santa Cruz Biotechnology
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Rpp20 CRISPR Activation Plasmid (h) - sc-410558-ACT from Santa Cruz Biotechnology
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Rpp20 CRISPR Activation Plasmid (h2) - sc-410558-ACT-2 from Santa Cruz Biotechnology
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Rpp20 Lentiviral Activation Particles (h) - sc-410558-LAC from Santa Cruz Biotechnology
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Rpp20 Lentiviral Activation Particles (h2) - sc-410558-LAC-2 from Santa Cruz Biotechnology
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Rpp20 siRNA (h) - sc-89498 from Santa Cruz Biotechnology
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Rpp20 shRNA Plasmid (h) - sc-89498-SH from Santa Cruz Biotechnology
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Rpp20 shRNA (h) Lentiviral Particles - sc-89498-V from Santa Cruz Biotechnology
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POP7 RNAi - H00010248-R01 from Novus Biologicals
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MISSION® esiRNA - EHU138361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17157 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17157 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01099 from Sigma-Aldrich
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POP7 siRNA (Human) - CRH6935 from Cohesion Biosciences
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shRNA set against Human POP7 (NM_005837.2) - SHH379853 from Creative biogene
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POP7 shRNA Plasmid (Human) - CHH6935 from Cohesion Biosciences
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POP7 miRNA 3'UTR clone - MiUTR1H-08099 from Creative biogene
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