Gene Symbol | Npr1 |
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Entrez Gene | 18160 |
Alt Symbol | AI893888, GC-A, NPR-A, NPRA, Pndr |
Species | Mouse |
Gene Type | protein-coding |
Description | natriuretic peptide receptor 1 |
Other Description | ANP-A|ANPR-A|Nppa receptor|atrial natriuretic peptide receptor 1|atrial natriuretic peptide receptor type A|guanylate cyclase A|guanylyl cyclase-A |
Swissprots | P18293 |
Accessions | CAC41350 EDL15140 P18293 AK135008 BAE22383 BC110659 AAI10660 BC139767 CJ065787 J05504 AAA37670 L31932 AAA66945 XM_006501114 XP_006501177 XR_375494 NM_008727 NP_032753 |
Function | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Purine metabolism |
NPR-A CRISPR/Cas9 KO Plasmid (m) - sc-421948 from Santa Cruz Biotechnology
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NPR-A HDR Plasmid (m) - sc-421948-HDR from Santa Cruz Biotechnology
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NPR-A Double Nickase Plasmid (m) - sc-421948-NIC from Santa Cruz Biotechnology
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NPR-A Double Nickase Plasmid (m2) - sc-421948-NIC-2 from Santa Cruz Biotechnology
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NPR-A CRISPR Activation Plasmid (m) - sc-421948-ACT from Santa Cruz Biotechnology
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NPR-A CRISPR Activation Plasmid (m2) - sc-421948-ACT-2 from Santa Cruz Biotechnology
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NPR-A Lentiviral Activation Particles (m) - sc-421948-LAC from Santa Cruz Biotechnology
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NPR-A Lentiviral Activation Particles (m2) - sc-421948-LAC-2 from Santa Cruz Biotechnology
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NPR-A siRNA (m) - sc-40126 from Santa Cruz Biotechnology
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NPR-A shRNA Plasmid (m) - sc-40126-SH from Santa Cruz Biotechnology
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NPR-A shRNA (m) Lentiviral Particles - sc-40126-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU040661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36625 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36625 from Sigma-Aldrich
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NPR1 siRNA (Mouse) - CRM2826 from Cohesion Biosciences
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shRNA set against Mouse NPR1 (NM_008727.5) - SHH354396 from Creative biogene
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shRNA set against Mouse Npr1(NM_008727.5) - SHR018840 from Creative biogene
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Mouse NPR1 siRNA - orb282302 from Biorbyt
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NPR1 shRNA Plasmid (Mouse) - CHM2826 from Cohesion Biosciences
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NPR1 miRNA 3'UTR clone - MiUTR1M-07782 from Creative biogene
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