SHFM1

Gene Symbol	SHFM1
Entrez Gene	7979
Alt Symbol	DSS1, ECD, SEM1, SHFD1, SHSF1, Shfdg1
Species	Human
Gene Type	protein-coding
Description	split hand/foot malformation (ectrodactyly) type 1
Other Description	26S proteasome complex subunit DSS1|deleted in split hand/split foot protein 1|deleted in split-hand/split-foot 1|split hand/foot deleted protein 1|split hand/foot malformation type 1 protein
Swissprots	P60896
Accessions	AAQ93368 EAL24125 EAW76746 EAW76747 P60896 AK094899 AK291070 BAF83759 AK309241 BC032782 AAH32782 CR456887 CAG33168 U41515 AAA91179 NM_006304 NP_006295
Function	Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription- associated genomic instability. R-loop accumulation increases in DSS1-depleted cells. {ECO:0000269|PubMed:15117943, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180}.
Tissue Specificity	Expressed in limb bud, craniofacial primordia and skin.
Top Pathways	Proteasome, Homologous recombination, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DSS1 full length protein - ab131993 from Abcam Category Protein Source Wheat germ Species Human

Human DSS1 full length protein - ab174412 from Abcam Category Protein Source E. coli Species Human

Human DSS1 peptide - ab23110 from Abcam Category Peptide Species Human

ECD Antibody Blocking Peptide - LS-E11621 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ECD Antibody Blocking Peptide - LS-E14027 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHSF1 / SHFM1 Antibody Blocking Peptide - LS-E25633 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GCR2 Protein - H00011319-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DSS1 Recombinant Protein - H00007979-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human DSS1 Protein - NBP2-22821 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

DSS1 blocking peptide - GTX25649-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Pig, Bovine

Human ECD protein (GST Tag) - orb138722 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

SHFM1 protein (His tag) - 80R-3573 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

DSS1 Peptide - AC21-0464-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SHFM1 (1-70, His-tag) - AR51260PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

SHFM1 (1-70, His-tag) - AR51260PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

SHFM1 - H00007979-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SHFM1 - H00007979-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SHFM1, 1-70aa, Human, His tag, E.coli - 01-P2440 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

DSS1 Peptide - 45-500P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

SHFM1 fusion protein - Ag4573 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SHFM1, GST-tagged - SHFM1-2659H from Creative Biomart Category Protein Source E.coli Species Human

Human ECD / Ecdysoneless homolog Protein (His & GST Tag) - 14311-H20B-50 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human 26S proteasome complex subunit DSS1(SHFM1) - CSB-YP021263HU CSB-EP021263HU CSB-BP021263HU CSB-MP021263HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SHFM1, 1-70aa, Human, His tag, E.coli - ATGP2440 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

26S proteasome complex subunit DSS1 (SHFM1), Recombinant Protein - MBS952957 from MyBioSource Category Protein Prices $800.00, $800.00, $1,025.00, $1,025.00, $1,120.00, $1,120.00, $1,580.00, $1,580.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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