| Gene Symbol | DHFR |
|---|---|
| Entrez Gene | 1719 |
| Alt Symbol | DHFRP1, DYR |
| Species | Human |
| Gene Type | protein-coding |
| Description | dihydrofolate reductase |
| Other Description | - |
| Swissprots | B4DDD2 P00374 Q6IRW8 Q14130 |
| Accessions | AAA58484 CAA25409 EAW95859 EAW95860 P00374 AA489055 AK293146 BAG56693 AK297302 BAG59770 AK308492 AK312642 BAG35526 BC000192 AAH00192 BC003584 AAH03584 BC009634 BC070280 AAH70280 BC071996 AAH71996 CB988944 DQ892816 ABM83742 DQ896062 ABM87061 EU145592 ABX57718 J00140 AAA58485 V00507 CAA23765 NM_000791 NP_000782 NM_001290354 NP_001277283 NM_001290357 NP_001277286 NR_110936 |
| Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}. |
| Tissue Specificity | Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. {ECO:0000269|PubMed:21310276}. |
| Top Pathways | Folate biosynthesis, One carbon pool by folate |