| Gene Symbol | GCNT2 |
|---|---|
| Entrez Gene | 2651 |
| Alt Symbol | CCAT, CTRCT13, GCNT2C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3, bA360O19.2, bA421M1.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) |
| Other Description | I beta-1,6-N-acetylglucosaminyltransferase|Ii blood group|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase|beta-1,6-N-acetylglucosaminyltransferase 2 |
| Swissprots | Q6T5E5 Q8N0V5 Q5T4J1 Q8NFS9 Q06430 Q5W0E9 |
| Accessions | AAA99832 EAW55259 EAW55260 EAW55261 EAW55262 Q06430 Q8N0V5 Q8NFS9 AB078432 BAC66781 AB078433 BAC66782 AF401652 AAL50561 AF401653 AAL50562 AF458024 AAM73864 AF458025 AAM73865 AF458026 AAM73866 AF458027 AAM73867 AF458028 AAM74524 AF458029 AAM73869 AF458030 AAM73870 AK090483 BAC03464 AK098105 BAC05234 AK291195 BAF83884 AK291767 BAF84456 AK307329 AK307337 AK307373 AK310216 AK313426 BAG36218 AK313903 BAG36626 AL832714 AL832719 AY435145 AAR95646 AY435146 AAR95647 AY435147 AAR95648 BC074801 AAH74801 BC074802 AAH74802 BC130524 AAI30525 BX503586 BX647576 CAI46081 BX647668 DB208581 HQ258240 ADR82994 L19659 AAA81777 Z19550 CAA79610 XM_005248997 XP_005249054 XM_005248999 XP_005249056 XM_006715052 XP_006715115 XM_006715053 XP_006715116 XM_011514465 XP_011512767 XM_011514466 XP_011512768 XM_011514467 XP_011512769 XM_011514468 XP_011512770 XR_926136 XR_926137 XR_926138 NM_001491 NP_001482 NM_145649 NP_663624 NM_145655 NP_663630 |
| Function | Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | In the adult, highly expressed in prostate and to a lesser extent in small intestine and colon. Barely detected in heart, brain, kidney and pancreas. No expression in placenta, lung, liver, skeletal muscle, spleen, thymus, testis, ovary and peripheral blood leukocytes. In fetus, highly expressed in brain and to a lesser extent in lung and kidney. Barely detected in liver. {ECO:0000269|PubMed:12424189, ECO:0000269|PubMed:9405606}. |
| Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |
GCNT2 CRISPR/Cas9 KO Plasmid (h) - sc-409177 from Santa Cruz Biotechnology
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GCNT2 HDR Plasmid (h) - sc-409177-HDR from Santa Cruz Biotechnology
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GCNT2 Double Nickase Plasmid (h) - sc-409177-NIC from Santa Cruz Biotechnology
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GCNT2 Double Nickase Plasmid (h2) - sc-409177-NIC-2 from Santa Cruz Biotechnology
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GCNT2 CRISPR Activation Plasmid (h) - sc-409177-ACT from Santa Cruz Biotechnology
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GCNT2 CRISPR Activation Plasmid (h2) - sc-409177-ACT-2 from Santa Cruz Biotechnology
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GCNT2 Lentiviral Activation Particles (h) - sc-409177-LAC from Santa Cruz Biotechnology
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GCNT2 Lentiviral Activation Particles (h2) - sc-409177-LAC-2 from Santa Cruz Biotechnology
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GCNT2 siRNA (h) - sc-95267 from Santa Cruz Biotechnology
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GCNT2 shRNA Plasmid (h) - sc-95267-SH from Santa Cruz Biotechnology
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GCNT2 shRNA (h) Lentiviral Particles - sc-95267-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU088911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9197 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9197 from Sigma-Aldrich
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GCNT2 siRNA (Human) - CRH1765 from Cohesion Biosciences
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GCNT2 siRNA (Human) - CRH1766 from Cohesion Biosciences
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GCNT2 siRNA (Human) - CRH1767 from Cohesion Biosciences
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GCNT2 - MBS8220724 from MyBioSource
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GCNT2 - MBS829628 from MyBioSource
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GCNT2 - MBS8212467 from MyBioSource
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shRNA set against Human GCNT2 (NM_001491.2) - SHH300118 from Creative biogene
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shRNA set against Human GCNT2(NM_001491.2) - SHH080335 from Creative biogene
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shRNA set against Human GCNT2(NM_145655.3) - SHH080417 from Creative biogene
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Human GCNT2 siRNA - orb262268 from Biorbyt
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Human GCNT2 siRNA - orb262269 from Biorbyt
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