Prkca

Gene Symbol	Prkca
Entrez Gene	24680
Alt Symbol	Pkca
Species	Rat
Gene Type	protein-coding
Description	protein kinase C, alpha
Other Description	PKC-A|PKC-alpha|protein kinase C alpha type
Swissprots	P05696
Accessions	EDM06446 P05696 BC169007 AAI69007 X07286 CAA30266 XM_008768310 XP_008766532 NM_001105713 NP_001099183
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive for
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Note=Translocated to the nucleus upon treatment with PMA or IGF1.
Top Pathways	Oxytocin signaling pathway, Sphingolipid signaling pathway, Proteoglycans in cancer, Morphine addiction, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Protein Kinase C Alpha (PKCa), Rat, ELISA Kit - SEB918Ra from ARP American Research Products Category ELISA Kit Prices $742.00 Sizes 96 t Sensitivity 0.237ng/mL Range 0.625-40ng/mL

Protein kinase C alpha type, Prkca, Rat, ELISA Kit - E1380r from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Protein kinase C, PKC, Rat, ELISA Kit - CSB-E12801r from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Rat PKCa ELISA Kit - RP0677 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Rat protein kinase C,PKC ELISA Kit - CSB-E12801r from Cusabio Category ELISA Kit Sensitivity 3.9 pg/ml. Range 15.6 pg/ml-1000 pg/ml

Rat Protein kinase C alpha ELISA - E02P0670 from BlueGene Biotech Category ELISA Kit

ELISA Kit for Protein Kinase C Alpha (PKCa) - SEB918Ra from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.237ng/mL. Range 0.625-40ng/mL The standard curve concentrations used for the ELISA's were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

Rat PKCa ELISA Kit - abx155977 from Abbexa Category ELISA Kit Sensitivity 0.237 ng/ml Range 0.625 ng/ml - 40 ng/ml

Protein Kinase C Alpha (PKCa), Rat, ELISA Kit - DL-PKCa-Ra from ARP American Research Products Category ELISA Kit Prices $715.00 Sizes 96 t Range 0.625-40 ng/mL

Rat PKCa ELISA Kit - abx573293 from Abbexa Category ELISA Kit Sensitivity 0.237 ng/ml Range 0.625 ng/ml - 40 ng/ml

Rat Prkca ELISA Kit - E087849 from Biobool Category ELISA Kit

Prkca ELISA Kit (Rat) (OKEH04840) - OKEH04840 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity < 0.15 ng/mL Range 31.2 - 2,000 pg/mL

Rat PKCa ELISA Kit - ERP0677 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Rat Protein kinase C alpha type ELISA Kit - EK3293 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.312-20 ng/mL

Rat Protein kinase C (PKC) ELISA Kit - AE25978RA from ARP American Research Products Category ELISA Kit Prices $680.00 Sizes 96 t Sensitivity 3.9 pg/mL Range 15.6-1000 pg/mL

kinase C alpha type, ELISA Kit - MBS2884943 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

kinase C alpha type, ELISA Kit - MBS9427127 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 0.312-20 ng/mL

Protein Kinase C Alpha (PKCa), ELISA Kit - MBS451314 from MyBioSource Category ELISA Kit Prices $425.00, $565.00, $2,485.00, $4,830.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.237ng/mL Range 0.625-40ng/mL

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