| Gene Symbol | Prkca |
|---|---|
| Entrez Gene | 24680 |
| Alt Symbol | Pkca |
| Species | Rat |
| Gene Type | protein-coding |
| Description | protein kinase C, alpha |
| Other Description | PKC-A|PKC-alpha|protein kinase C alpha type |
| Swissprots | P05696 |
| Accessions | EDM06446 P05696 BC169007 AAI69007 X07286 CAA30266 XM_008768310 XP_008766532 NM_001105713 NP_001099183 |
| Function | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive for |
| Subcellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Note=Translocated to the nucleus upon treatment with PMA or IGF1. |
| Top Pathways | Oxytocin signaling pathway, Sphingolipid signaling pathway, Proteoglycans in cancer, Morphine addiction, Rap1 signaling pathway |
CompoZr® Knockout ZFN Kit - CKOZFN60579 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND60579 from Sigma-Aldrich
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shRNA set against Rat PRKCA (NM_001105713.1) - SHH382788 from Creative biogene
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shRNA set against Rat Prkca(NM_001105713.1) - SHR140190 from Creative biogene
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PRKCA miRNA 3'UTR clone - MiUTR1R-06053 from Creative biogene
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