| Gene Symbol |
AUP1
|
| Entrez Gene |
550
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ancient ubiquitous protein 1
|
| Other Description |
-
|
| Swissprots |
Q9UNQ6 C0H5W8 Q9H866 Q9Y679 Q9Y685
|
| Accessions |
EAW99622 EAW99623 EAW99624 EAW99625 Q9Y679 AF100746 AAD43010 AF100753 AAD43017 AF100754 AAD43018 AF165515 AAF86645 AI206563 AI580873 AK023983 BAB14753 AK055566 AK293121 BAF85810 AK301398 BAG62933 AK304886 BAG65623 AK308231 AK310159 BC001658 AAH01658 BC033646 AAH33646 CR749661 CAH18454 CR999537 CX164419 EU831790 ACE87308 EU831868 ACE86627 HY078082 XM_005264392 XP_005264449 NM_181575 NP_853553 NR_126510 NR_126511
|
| Function |
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. {ECO:0000269|PubMed:18711132}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12042322, ECO:0000269|PubMed:18711132}; Single-pass type III membrane protein {ECO:0000269|PubMed:12042322, ECO:0000269|PubMed:18711132}; Cytoplasmic side {ECO:0000269|PubMed:12042322, ECO:0000269|PubMed:18711132}.
|
| Tissue Specificity |
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12042322}.
|