Gene Symbol | TAS2R14 |
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Entrez Gene | 50840 |
Alt Symbol | T2R14, TRB1 |
Species | Human |
Gene Type | protein-coding |
Description | taste receptor, type 2, member 14 |
Other Description | taste receptor family B member 1|taste receptor type 2 member 14|taste receptor, family B, member 1 |
Swissprots | Q645X3 Q9NYV8 |
Accessions | AAF43911 BAD98002 BAD98003 BAD98004 CAI53561 EAW96222 Q9NYV8 AK123548 BAC85643 BC069148 AAH69148 BC101993 AAI01994 BC101994 AAI01995 BC103699 AAI03700 NM_023922 NP_076411 |
Function | Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. |
Top Pathways | Taste transduction |
T2R14 CRISPR/Cas9 KO Plasmid (h) - sc-410582 from Santa Cruz Biotechnology
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T2R14 HDR Plasmid (h) - sc-410582-HDR from Santa Cruz Biotechnology
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T2R14 Double Nickase Plasmid (h) - sc-410582-NIC from Santa Cruz Biotechnology
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T2R14 Double Nickase Plasmid (h2) - sc-410582-NIC-2 from Santa Cruz Biotechnology
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T2R14 CRISPR Activation Plasmid (h) - sc-410582-ACT from Santa Cruz Biotechnology
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T2R14 CRISPR Activation Plasmid (h2) - sc-410582-ACT-2 from Santa Cruz Biotechnology
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T2R14 Lentiviral Activation Particles (h) - sc-410582-LAC from Santa Cruz Biotechnology
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T2R14 Lentiviral Activation Particles (h2) - sc-410582-LAC-2 from Santa Cruz Biotechnology
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T2R14 siRNA (h) - sc-95889 from Santa Cruz Biotechnology
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T2R14 shRNA Plasmid (h) - sc-95889-SH from Santa Cruz Biotechnology
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T2R14 shRNA (h) Lentiviral Particles - sc-95889-V from Santa Cruz Biotechnology
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TAS2R14 RNAi - H00050840-R02 from Novus Biologicals
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MISSION® esiRNA - EHU230201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21015 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21015 from Sigma-Aldrich
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TAS2R14 siRNA (Human) - CRH9421 from Cohesion Biosciences
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TAS2R14 - MBS8210007 from MyBioSource
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shRNA set against Human TAS2R14 (NM_023922.1) - SHH423464 from Creative biogene
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TAS2R14 shRNA Plasmid (Human) - CHH9421 from Cohesion Biosciences
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TAS2R14 miRNA 3'UTR clone - MiUTR1H-10193 from Creative biogene
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