| Gene Symbol |
KLF11
|
| Entrez Gene |
8462
|
| Alt Symbol |
FKLF, FKLF1, MODY7, TIEG2, Tieg3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kruppel-like factor 11
|
| Other Description |
Krueppel-like factor 11|TGFB-inducible early growth response protein 2|TIEG-2|transforming growth factor-beta-inducible early growth response protein 2
|
| Swissprots |
Q9EPF4 O14901 B4DZE7
|
| Accessions |
AAX93098 CAH23425 CAH33945 EAX00972 O14901 AF028008 AAC61880 AF272830 AAF75793 AI183650 AI755210 AJ275989 CAC06699 AK002186 AK289816 BAF82505 AK302880 BAG64059 AK315345 BAG37743 AK316439 BAH14810 BC063286 AAH63286 BC069383 AAH69383 BC074922 AAH74922 BG701929 BM548792 BQ881155 CB990375 XM_005246179 XP_005246236 NM_001177716 NP_001171187 NM_001177718 NP_001171189 NM_003597 NP_003588
|
| Function |
Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. {ECO:0000269|PubMed:10207080}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Ubiquitous. Higher expression in erythroid cells. {ECO:0000269|PubMed:10207080}.
|